Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1978 Jun;20(3):869–872. doi: 10.1128/iai.20.3.869-872.1978

Characterization of the TO strains of Theiler's mouse encephalomyelitis viruses.

H L Lipton
PMCID: PMC421941  PMID: 208981

Abstract

Theiler's mouse encephalomyelitis virus isolates from the central nervous systems of spontaneously paralyzed mice and stools of asymptomatic mice resemble Theiler's original virus isolates. In this study four such strains were adapted by blind subpassage to replicate and to produce cytopathic effect in cell culture. These viruses were then found to be closely related to each other and to GDVII virus by cross-neutralization and to form small plaques. Bovine serum was found to contain cross-reacting antibodies to these viruses.

Full text

PDF
869

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Calisher C. H., Rowe W. P. Mouse hepatitis, reo-3, and the Theiler viruses. Natl Cancer Inst Monogr. 1966 Feb;20:67–75. [PubMed] [Google Scholar]
  2. Dal Canto M. C., Lipton H. L. Primary demyelination in Theiler's virus infection. An ultrastructural study. Lab Invest. 1975 Dec;33(6):626–637. [PubMed] [Google Scholar]
  3. Graves J. H. Serological relationship of swine vesicular disease virus and Coxsackie B5 virus. Nature. 1973 Oct 12;245(5424):314–315. doi: 10.1038/245314a0. [DOI] [PubMed] [Google Scholar]
  4. Hemelt I. E., Huxsoll D. L., Warner A. R., Jr Comparison of MHG virus with mouse encephalomyelitis viruses. Lab Anim Sci. 1974 Jun;24(3):523–529. [PubMed] [Google Scholar]
  5. Lipton H. L. Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination. Infect Immun. 1975 May;11(5):1147–1155. doi: 10.1128/iai.11.5.1147-1155.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. SHAW M. Serologic studies of Theiler's mouse encephalomyelitis virus. Proc Soc Exp Biol Med. 1956 Jun;92(2):390–390. doi: 10.3181/00379727-92-22487. [DOI] [PubMed] [Google Scholar]
  7. Sturman L. S., Tamm I. Host dependence of GDVII virus: complete or abortive multiplication in various cell types. J Immunol. 1966 Dec;97(6):885–896. [PubMed] [Google Scholar]
  8. THOMPSON R., HARRISON V. M., MYERS F. P. A spontaneous epizootic of mouse encephalomyelitis. Proc Soc Exp Biol Med. 1951 Jun;77(2):262–266. doi: 10.3181/00379727-77-18744. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES