Abstract
Inactivated Brucella abortus organisms of the smooth (S) or rough (R) strain were tested comparatively on two T-dependent immune responses: mixed-lymphocyte reaction and delayed-type hypersensitivity. The intravenous injection of S organisms depressed the two tests, whereas R organisms increased mixed-lymphocyte reaction and did not alter delayed-type hypersensitivity significantly. This observation may be helpful in understanding the differences in adjuvant properties of S and R brucellae.
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Selected References
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