Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1978 Nov;22(2):371–377. doi: 10.1128/iai.22.2.371-377.1978

Hyporeactivity factor produced after induction of immune interferon in mice sensitized with BCG.

T Minagawa, M Ho
PMCID: PMC422165  PMID: 365756

Abstract

Sera from BCG-sensitized ICR and C57BL/10J mice challenged with BCG were examined. Two types of hyporeactive factor (HF), which produced refractoriness to induction of interferon (IF) by Newcastle disease virus in mouse embryo fibroblasts, were produced in addition to type II immune IF. One was destroyed at pH 2, and the other was not. The acid-labile HF, together with immune IF, appeared 2 h after challenge with BCG. Acid-labile HF and immune IF were not neutralized by antiserum against L-cell IF and may be one substance. On the other hand, acid-stable HF appeared later and was neutralized by antiserum against L-cell IF. Furthermore, acid-stable HF was more stable at 56 degrees C than were immune IF and pH-labile HF. Induction of IF by Newcastle disease virus was also reduced in mice 6 h after receiving one injection of BCG, irrespective of whether the animals were previously sensitized to BCG.

Full text

PDF
371

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrews P. Estimation of the molecular weights of proteins by Sephadex gel-filtration. Biochem J. 1964 May;91(2):222–233. doi: 10.1042/bj0910222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Armstrong J. A. Semi-micro, dye-binding assay for rabbit interferon. Appl Microbiol. 1971 Apr;21(4):723–725. doi: 10.1128/am.21.4.723-725.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Borden E. C., Murphy F. A. The interferon refractory state: in vivo and in vitro studies of its mechanism. J Immunol. 1971 Jan;106(1):134–142. [PubMed] [Google Scholar]
  4. Davey M. W., Huang J. W., Sulkowski E., Carter W. A. Hydrophobic interaction of human interferon with concanavalin A-agarose. J Biol Chem. 1974 Oct 10;249(19):6354–6355. [PubMed] [Google Scholar]
  5. Ho M., Armstrong J. A. Interferon. Annu Rev Microbiol. 1975;29:131–161. doi: 10.1146/annurev.mi.29.100175.001023. [DOI] [PubMed] [Google Scholar]
  6. Ho M., Kono Y., Breinig M. K. Tolerance to the induction of interferons by endotoxin and virus: role of a humoral factor. Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1227–1232. doi: 10.3181/00379727-119-30421. [DOI] [PubMed] [Google Scholar]
  7. Maehara N., Ho M. Cellular origin of interferon induced by bacterial lipopolysaccharide. Infect Immun. 1977 Jan;15(1):78–83. doi: 10.1128/iai.15.1.78-83.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nagano Y., Mizunoe K., Maehara N., Kumazawa Y. Induction of virus-inhibiting factor or interferon by cell fractions of Mycobacterium tuberculosis. Jpn J Microbiol. 1971 Nov;15(6):542–544. doi: 10.1111/j.1348-0421.1971.tb00617.x. [DOI] [PubMed] [Google Scholar]
  9. Paucker K., Boxaca M. Cellular resistance to induction of interferon. Bacteriol Rev. 1967 Jun;31(2):145–156. doi: 10.1128/br.31.2.145-156.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Salvin S. B., Youngner J. S., Lederer W. H. Migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. Infect Immun. 1973 Jan;7(1):68–75. doi: 10.1128/iai.7.1.68-75.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sonnenfeld G., Mandel A. D., Merigan T. C. The immunosuppressive effect of type II mouse interferon preparations on antibody production. Cell Immunol. 1977 Dec;34(2):193–206. doi: 10.1016/0008-8749(77)90243-x. [DOI] [PubMed] [Google Scholar]
  12. Stringfellow D. A. Hyporeactivity to interferon induction: characterization of a hyporeactive factor in the serum of encephalomyocarditis virus-infected mice. Infect Immun. 1975 Feb;11(2):294–302. doi: 10.1128/iai.11.2.294-302.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tarr G. C., Armstrong J. A., Ho M. Production of interferon and serum hyporeactivity factor in mice infected with murine cytomegalovirus. Infect Immun. 1978 Mar;19(3):903–907. doi: 10.1128/iai.19.3.903-907.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Youngner J. S., Hallum J. V. Inhibition of induction of interferon synthesis in L-cells pretreated with interferon. Virology. 1969 Mar;37(3):473–475. doi: 10.1016/0042-6822(69)90231-1. [DOI] [PubMed] [Google Scholar]
  15. Youngner J. S., Salvin S. B. Production and properties of migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity. J Immunol. 1973 Dec;111(6):1914–1922. [PubMed] [Google Scholar]
  16. Youngner J. S., Stinebring W. R. Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis. Nature. 1965 Oct 30;208(5009):456–458. doi: 10.1038/208456a0. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES