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. 1978 Nov;22(2):430–434. doi: 10.1128/iai.22.2.430-434.1978

Bordetella pertussis does not induce beta-adrenergic blockade.

E Hewlett, A Spiegel, J Wolff, G Aurbach, C R Manclark
PMCID: PMC422174  PMID: 32138

Abstract

Bordetella pertussis organisms induce histamine sensitivity and diminish the normal hyperglycemic response to epinephrine in experimental animals. These effects have been attributed to beta-adrenergic blockade. However, under conditions in which the decrease in epinephrine-induced hyperglycemia after B. pertussis administration was demonstrable, there was no change in rat reticulocyte beta-adrenergic receptor number or affinity measured by iodohydroxybenzylpindolol binding or in isoproterenol-stimulated adenylate cyclase activity. Therefore, there was no generalized beta-adrenergic blockade induced by B. pertussis. The observed effects can be explained by the hypersecretion of insulin resulting from B. pertussis administration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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