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. 1978 Nov;22(2):441–444. doi: 10.1128/iai.22.2.441-444.1978

Chemotactic deactivation of human neutrophils: evidence for nonspecific and specific components.

R D Nelson, R T McCormack, V D Fiegel, R L Simmons
PMCID: PMC422176  PMID: 730365

Abstract

Human polymorphonuclear neutrophils have been preexposed to activated complement as zymosan-activated serum (ZAS) or to the chemotactic oligopeptide N-formyl methionylphenylalanine (F-Met-Phe). Spontaneous migration and chemotactic responses toward the deactivating and other cytotaxins were monitored after washing and resuspension of cells in cytotaxin-free medium. Two patterns of deactivation were observed. Preexposure of the leukocytes to high doses of ZAS or F-Met-Phe decreased all subsequent migratory responses. Preexposure of the leukocytes to lower doses of ZAS or F-Met-Phe decreased only a subsequent chemotactic response to the deactivating cytotaxin. These results suggest two mechanisms, or components, of chemotactic deactivation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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