Scheme 1.
Synthesis of p-KTAA and HS-42. Reagents and conditions: a) NBS, DMF, 0 °C to RT, 16 h; b) 1,4-dioxane/MeOH, PEPPSI™-IPr, K2CO3, 70 °C, 20 min; c) NaOH (1 m), 1,4-doxane, 60 °C, 16 h.
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