Abstract
Intravenous injection of toxic doses of Chlamydia psittaci elementary bodies into endotoxin-responsive C3H/HeN mice or endotoxin-nonresponsive C3H/HeJ mice resulted in essentially identical time intervals to death. Inoculation of monolayer cultures of thioglycolate-stimulated peritoneal macrophages from the two strains of mice with 250 elementary bodies per macrophage resulted in immediate host cell toxicity, although the C3H/HeJ macrophages were somewhat less sensitive to elementary body toxicity than were the C3H/HeN macrophages.
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Selected References
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- BENEDICT A. A., O'BRIEN E. Antigenic studies on the psittacosis-lymphogranuloma venereum group of viruses. II. Characterization of complement-fixing antigens extracted with sodium lauryl sulfate. J Immunol. 1956 Apr;76(4):293–300. [PubMed] [Google Scholar]
- Chedid L., Parant M., Damais C., Parant F., Juy D., Galelli A. Failure of endotoxin to increase nonspecific resistance to infection of lipopolysaccharide low-responder mice. Infect Immun. 1976 Mar;13(3):722–727. doi: 10.1128/iai.13.3.722-727.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dhir S. P., Hakomori S., Kenny G. E., Grayston J. T. Immunochemical studies on chlamydial group antigen (presence of a 2-keto-3-deoxycarbohydrate as immunodominant group). J Immunol. 1972 Jul;109(1):116–122. [PubMed] [Google Scholar]
- Dhir S. P., Kenny G. E., Grayston J. T. Characterization of the group antigen of Chlamydia trachomatis. Infect Immun. 1971 Dec;4(6):725–730. doi: 10.1128/iai.4.6.725-730.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glode L. M., Jacques A., Mergenhagen S. E., Rosenstreich D. L. Resistance of macrophages from C3H/HeJ mice to the in vitro cytotoxic effects of endotoxin. J Immunol. 1977 Jul;119(1):162–166. [PubMed] [Google Scholar]
- JENKIN H. M. Preparation and properties of cell walls of the agent of meningopneumonitis. J Bacteriol. 1960 Nov;80:639–647. doi: 10.1128/jb.80.5.639-647.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MANIRE G. P., MEYER K. F. The toxins of the psittacosis-lymphogranuloma group of agents; effect of aureomycin and penicillin upon the toxins of psittacosis viruses. J Infect Dis. 1950 May-Jun;86(3):233–240. doi: 10.1093/infdis/86.3.233. [DOI] [PubMed] [Google Scholar]
- Manire G. P., Tamura A. Preparation and chemical composition of the cell walls of mature infectious dense forms of meningopneumonitis organisms. J Bacteriol. 1967 Oct;94(4):1178–1183. doi: 10.1128/jb.94.4.1178-1183.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moulder J. W., Hatch T. P., Byrne G. I., Kellogg K. R. Immediate toxicity of high multiplicities of Chlamydia psittaci for mouse fibroblasts (L cells). Infect Immun. 1976 Jul;14(1):277–289. doi: 10.1128/iai.14.1.277-289.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Narita T., Manire G. P. Protein-carbohydrate-lipid complex isolated from the cell envelopes of Chlamydia psittaci in alkaline buffer and ethylenediaminetetraacetate. J Bacteriol. 1976 Jan;125(1):308–316. doi: 10.1128/jb.125.1.308-316.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Skidmore B. J., Chiller J. M., Morrison D. C., Weigle W. O. Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities. J Immunol. 1975 Feb;114(2 Pt 2):770–775. [PubMed] [Google Scholar]
- Sultzer B. M. Genetic control of leucocyte responses to endotoxin. Nature. 1968 Sep 21;219(5160):1253–1254. doi: 10.1038/2191253a0. [DOI] [PubMed] [Google Scholar]
- Sultzer B. M., Nilsson B. S. PPD tuberculin--a B-cell mitogen. Nat New Biol. 1972 Dec 13;240(102):198–200. doi: 10.1038/newbio240198a0. [DOI] [PubMed] [Google Scholar]
- Taverne J., Blyth W. A., Ballard R. C. Interactions of TRIC agents with macrophages: effects on lysosomal enzymes of the cell. J Hyg (Lond) 1974 Apr;72(2):297–309. doi: 10.1017/s0022172400023512. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wang S. P., Grayston J. T. A potency test for trachoma vaccine utilizing the mouse toxicity prevention test. Am J Ophthalmol. 1967 May;63(5 Suppl):1443–1454. doi: 10.1016/0002-9394(67)94130-x. [DOI] [PubMed] [Google Scholar]
- Wang S. P., Kenny G. E., Grayston J. T. Characterization of trachoma antigens protective against mouse toxicity. Am J Ophthalmol. 1967 May;63(5 Suppl):1454–1461. doi: 10.1016/0002-9394(67)94131-1. [DOI] [PubMed] [Google Scholar]
- Watson J., Riblet R. Genetic control of responses to bacterial lipopolysaccharides in mice. I. Evidence for a single gene that influences mitogenic and immunogenic respones to lipopolysaccharides. J Exp Med. 1974 Nov 1;140(5):1147–1161. doi: 10.1084/jem.140.5.1147. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wyrick P. B., Brownridge E. A. Growth of Chlamydia psittaci in macrophages. Infect Immun. 1978 Mar;19(3):1054–1060. doi: 10.1128/iai.19.3.1054-1060.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wyrick P. B., Brownridge E. A., Ivins B. E. Interaction of Chlamydia psittaci with mouse peritoneal macrophages. Infect Immun. 1978 Mar;19(3):1061–1067. doi: 10.1128/iai.19.3.1061-1067.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
