Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1978 Dec;22(3):657–664. doi: 10.1128/iai.22.3.657-664.1978

Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice.

R M Nakamura, T Tokunaga
PMCID: PMC422210  PMID: 365763

Abstract

Delayed-type hypersensitivity to BCG was remarkably different in two inbred strains of mice, SWM/Ms and C3H/He, when measured by the spleen index, the disappearance of peritoneal macrophage, or the footpad reaction. High responsiveness in the SWM/Ms strain appeared to be dominant over low responsiveness in the C3H/He strain. Results of the footpad reaction test if F1, F2, and backcross hybrids of these two strains of mice suggested that the delayed-type hypersensitivity was mainly controlled by a gene which was transmitted under Mendel's laws and was possibly non-H-2 linked. The spleen cells and their nylon wool nonadherent fraction from BCG-infected C3H/He mice were not reactive to purified protein derivative in vitro, whereas both the spleen cells and the nylon wool nonadherent fraction from BCG-infected SWM/Ms mice reacted well to purified protein derivative. Possible mechanisms of the different responses in the delayed-type hypersensitivity to BCG were discussed.

Full text

PDF
657

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen E. M., Moore V. L., Stevens J. O. Strain variation in BCG-induced chronic pulmonary inflammation in mice. I. Basic model and possible genetic control by non-H-2 genes. J Immunol. 1977 Jul;119(1):343–347. [PubMed] [Google Scholar]
  2. Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
  3. Civil R. H., Mahmoud A. A. Genetic differences in BCG-induced resistance to Schistosoma mansoni are not controlled by genes within the major histocompatibility complex of the mouse. J Immunol. 1978 Mar;120(3):1070–1072. [PubMed] [Google Scholar]
  4. Davis S., Shearer G. M., Mozes E., Sela M. Genetic control of the murine cell-mediated immune response in vivo. II. H-2 linked responsiveness to the synthetic polypeptide poly(Tyr,Glu)-poly(DL-Ala)--poly(Lys). J Immunol. 1975 Dec;115(6):1530–1532. [PubMed] [Google Scholar]
  5. Fachet J., Andó I. Genetic control of contact sensitivity to oxazolone in inbred, H-2 congenic and intra-H-2 recombinant strains of mice. Eur J Immunol. 1977 Apr;7(4):223–226. doi: 10.1002/eji.1830070407. [DOI] [PubMed] [Google Scholar]
  6. Gasser D. L. Genetic control of the immune response in mice. I. Segregation data and localization to the fifth linkage group of a gene affecting antibody production. J Immunol. 1969 Jul;103(1):66–70. [PubMed] [Google Scholar]
  7. Gasser D. L., Silvers W. K. Genetic determinants of immunological responsiveness. Adv Immunol. 1974;18:1–66. doi: 10.1016/s0065-2776(08)60307-7. [DOI] [PubMed] [Google Scholar]
  8. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  9. Karakoz I., Krejci J., Hála K., Blaszczyk B., Hraba T., Pekárek J. Genetic determination of tuberculin hypersensitivity in chicken inbred lines. Eur J Immunol. 1974 Aug;4(8):545–548. doi: 10.1002/eji.1830040805. [DOI] [PubMed] [Google Scholar]
  10. Mackaness G. B., Auclair D. J., Lagrange P. H. Immunopotentiation with BCG. I. Immune response to different strains and preparations. J Natl Cancer Inst. 1973 Nov;51(5):1655–1667. doi: 10.1093/jnci/51.5.1655. [DOI] [PubMed] [Google Scholar]
  11. McDevitt H. O., Benacerraf B. Genetic control of specific immune responses. Adv Immunol. 1969;11:31–74. doi: 10.1016/s0065-2776(08)60477-0. [DOI] [PubMed] [Google Scholar]
  12. Mozes E., Shearer G. M., Sela M. Cellular basis of the genetic control of immune responses to synthetic polypeptides. I. Differences in frequency of splenic precursor cells specific for a synthetic polypeptide derived from multichain polyproline ((T,G)-Pro--L) in high and low responder inbred mouse strains. J Exp Med. 1970 Oct 1;132(4):613–622. doi: 10.1084/jem.132.4.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. NELSON D. S., BOYDEN S. V. The loss of macrophages from peritoneal exudates following the injection of antigens into guinea-pigs with delayed-type hypersensitivity. Immunology. 1963 May;6:264–275. [PMC free article] [PubMed] [Google Scholar]
  14. Nomoto K., Makidono R., Takeya K. Immune response against hamster erythrocytes in the low-responder mouse strains. IV. Delayed hypersensitivity against solubilized hamster erythrocytes in mice. Jpn J Microbiol. 1972 Sep;16(5):415–423. doi: 10.1111/j.1348-0421.1972.tb00676.x. [DOI] [PubMed] [Google Scholar]
  15. Polák L., Barnes J. M., Turk J. L. The genetic control of contact sensitization to inorganic metal compounds in guinea-pigs. Immunology. 1968 May;14(5):707–711. [PMC free article] [PubMed] [Google Scholar]
  16. Rosenstreich D. L., Glode L. M. Difference in B cell mitogen responsiveness between closely related strains of mice. J Immunol. 1975 Sep;115(3):777–780. [PubMed] [Google Scholar]
  17. Ruco L. P., Meltzer M. S. Defective tumoricidal capacity of macrophages from C3H/HeJ mice. J Immunol. 1978 Jan;120(1):329–334. [PubMed] [Google Scholar]
  18. Tokunaga T., Yamamoto S., Nakamura R. M., Kataoka T. Immunotherapeutic and immunoprophylactic effects of BCG on 3-methylcholanthrene-induced autochthonous tumors in Swiss mice. J Natl Cancer Inst. 1974 Aug;53(2):459–463. doi: 10.1093/jnci/53.2.459. [DOI] [PubMed] [Google Scholar]
  19. Tokunaga T., Yamamoto S., Nakamura R. M., Kurosawa A., Murohashi T. Mouse-strain difference in immunoprophylactic and immunotherapeutic effects of BCG on carcinogen-induced autochthonous tumors. Jpn J Med Sci Biol. 1978 Apr;31(2):143–154. doi: 10.7883/yoken1952.31.143. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES