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. 1972 Feb;5(2):155–159. doi: 10.1128/iai.5.2.155-159.1972

Experimental Venezuelan Equine Encephalomyelitis Virus Infection of the Bovine

Thomas E Walton 1, Karl M Johnson 1
PMCID: PMC422339  PMID: 4564396

Abstract

Two groups of four dairy cows (Bos taurus) were infected subcutaneously with the epizootic Venezuelan equine encephalomyelitis virus (VEE) strains MF-8 and San Pelayo, respectively. Animals experienced no clinical illness, but all developed significant neutropenia. Virus was recovered once each from the blood of three animals but did not exceed 102.2 SMICLD50 (Suckling mouse intracerebral lethal dose50)/ml. Specific neutralizing antibodies appeared in the serum of all animals, but there were no significant differences in titers against different naturally occurring VEE subtypes. Dairy cattle thus appear to play no role in virus transmission during VEE epizootics but may serve as retrospective immunological sentinels of virus activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beck C. E., Wyckoff R. W. VENEZUELAN EQUINE ENCEPHALOMYELITIS. Science. 1938 Dec 2;88(2292):530–530. doi: 10.1126/science.88.2292.530. [DOI] [PubMed] [Google Scholar]
  2. Davis M. H., Hogge A. L., Jr, Ferrell J. F., Corristan E. C. Mosquito transmission of Venezuelan equine encephalomyelitis virus from experimentally infected frogs. Am J Trop Med Hyg. 1966 Mar;15(2):227–230. doi: 10.4269/ajtmh.1966.15.227. [DOI] [PubMed] [Google Scholar]
  3. Earley E., Peralta P. H., Johnson K. M. A plaque neutralization method for arboviruses. Proc Soc Exp Biol Med. 1967 Jul;125(3):741–747. doi: 10.3181/00379727-125-32194. [DOI] [PubMed] [Google Scholar]
  4. Franck P. T., Johnson K. M. An outbreak of Venezuelan encephalitis in man in the Panamá Canal Zone. Am J Trop Med Hyg. 1970 Sep;19(5):860–865. doi: 10.4269/ajtmh.1970.19.860. [DOI] [PubMed] [Google Scholar]
  5. Franck P. T., Johnson K. M. An outbreak of Venezuelan equine encephalomeylitis in Central America. Evidence for exogenous source of a virulent virus subtype. Am J Epidemiol. 1971 Nov;94(5):487–495. doi: 10.1093/oxfordjournals.aje.a121346. [DOI] [PubMed] [Google Scholar]
  6. Henderson B. E., Chappell W. A., Johnston J. G., Jr, Sudia W. D. Experimental infection of horses with three strains of Venezuelan equine encephalomyelitis virus. I. Clinical and virological studies. Am J Epidemiol. 1971 Mar;93(3):194–205. doi: 10.1093/oxfordjournals.aje.a121246. [DOI] [PubMed] [Google Scholar]
  7. Hinman A. R., McGowan J. E., Jr, Henderson B. E. Venezuelan equine encephalomyelitis: surveys of human illness during an epizootic in Guatemala and El Salvador. Am J Epidemiol. 1971 Feb;93(2):130–136. doi: 10.1093/oxfordjournals.aje.a121233. [DOI] [PubMed] [Google Scholar]
  8. Johnson K. M., Shelokov A., Peralta P. H., Dammin G. J., Young N. A. Recovery of Venezuelan equine encephalomyelitis virus in Panama. A fatal case in man. Am J Trop Med Hyg. 1968 May;17(3):432–440. doi: 10.4269/ajtmh.1968.17.432. [DOI] [PubMed] [Google Scholar]
  9. KISSLING R. E., CHAMBERLAIN R. W., NELSON D. B., STAMM D. D. Venezuelan equine encephalomyelitis in horses. Am J Hyg. 1956 May;63(3):274–287. doi: 10.1093/oxfordjournals.aje.a119811. [DOI] [PubMed] [Google Scholar]
  10. Kubes V., Ríos F. A. THE CAUSATIVE AGENT OF INFECTIOUS EQUINE ENCEPHALOMYELITIS IN VENEZUELA. Science. 1939 Jul 7;90(2323):20–21. doi: 10.1126/science.90.2323.20. [DOI] [PubMed] [Google Scholar]
  11. Kubes V. VENEZUELAN-TYPE EQUINE ENCEPHALOMYELITIS VIRUS IN TRINIDAD. Science. 1944 Jan 14;99(2559):41–42. doi: 10.1126/science.99.2559.41. [DOI] [PubMed] [Google Scholar]
  12. Randall R., Mills J. W. FATAL ENCEPHALITIS IN MAN DUE TO THE VENEZUELAN VIRUS OF EQUINE ENCEPHALOMYELITIS IN TRINIDAD. Science. 1944 Mar 17;99(2568):225–226. doi: 10.1126/science.99.2568.225. [DOI] [PubMed] [Google Scholar]
  13. SANMARTIN-BARBERI C., GROOT H., OSORNO-MESA E. Human epidemic in Colombia caused by the Venezuelan equine encephalomyelitis virus. Am J Trop Med Hyg. 1954 Mar;3(2):283–293. doi: 10.4269/ajtmh.1954.3.283. [DOI] [PubMed] [Google Scholar]
  14. SELLERS R. F., BERGOLD G. H., SUAREZ O. M., MORALES A. INVESTIGATIONS DURING VENEZUELAN EQUINE ENCEPHALITIS OUTBREAKS IN VENEZUELA--1962-1964. Am J Trop Med Hyg. 1965 May;14:460–469. doi: 10.4269/ajtmh.1965.14.460. [DOI] [PubMed] [Google Scholar]
  15. Sidwell R. W., Gebhardt L. P., Thorpe B. D. Epidemiological aspects of venezuelan equine encephalitis virus infections. Bacteriol Rev. 1967 Mar;31(1):65–81. doi: 10.1128/br.31.1.65-81.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sudia W. D., Lord R. D., Newhouse V. F., Miller D. L., Kissling R. E. Vector-host studies of an epizootic of Venezuelan equine encephalomyelitis in Guatemala, 1969. Am J Epidemiol. 1971 Feb;93(2):137–143. doi: 10.1093/oxfordjournals.aje.a121234. [DOI] [PubMed] [Google Scholar]
  17. Suárez O. M., Bergold G. H. Investigations of an outbreak of Venezuelan equine encephalitis in towns of eastern Venezuela. Am J Trop Med Hyg. 1968 Nov;17(6):875–880. doi: 10.4269/ajtmh.1968.17.875. [DOI] [PubMed] [Google Scholar]
  18. Young N. A., Johnson K. M. Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significance. Am J Epidemiol. 1969 Mar;89(3):286–307. doi: 10.1093/oxfordjournals.aje.a120942. [DOI] [PubMed] [Google Scholar]

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