Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1972 Feb;5(2):180–182. doi: 10.1128/iai.5.2.180-182.1972

Fatal Anaphylaxis-Like Reaction Induced by Yeast Mannans in Nonsensitized Mice

L S Kind 1, P K Kaushal 1, P Drury 1
PMCID: PMC422345  PMID: 4117879

Abstract

Some yeast mannans increased vascular permeability and caused anaphylaxis-like reactions, fatal in some cases, in nonsensitized CFW mice. In SWR mice deficient in the complement system component C5, anaphylactic shock did not develop after the injection of mannans but was readily induced by goat serum after the mice had been sensitized with Bordetella pertussis and goat serum. The observed biological activity of the yeast mannans appears to depend upon the α(1 → 2) and α(1 → 6) linkages in their main chain. Their relative inactivity in C5-deficient mice and the consumption of whole hemolytic complement after their addition to normal mouse serum suggest that yeast mannans may activate late-acting complement components to produce anaphylatoxin from complement components C5 and C3.

Full text

PDF
180

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ballou C. E. A study of the immunochemistry of three yeast mannans. J Biol Chem. 1970 Mar 10;245(5):1197–1203. [PubMed] [Google Scholar]
  2. CINADER B., DUBISKI S., WARDLAW A. C. DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT. J Exp Med. 1964 Nov 1;120:897–924. doi: 10.1084/jem.120.5.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gorin P. A., Spencer J. F. Structural chemistry of fungal polysaccharides. Adv Carbohydr Chem Biochem. 1968;23:367–417. doi: 10.1016/s0096-5332(08)60172-1. [DOI] [PubMed] [Google Scholar]
  4. Kind L. S., Banovitz J., Menzel A., Nilsson B. A factor in pollen which enhances vascular permeability. J Allergy. 1967 Jan;39(1):17–24. doi: 10.1016/0021-8707(67)90122-0. [DOI] [PubMed] [Google Scholar]
  5. Kind L. S., Macedo-Sobrinho B., Ako D. Enhanced vascular permeability induced in mice by larch arabinogalactan. Immunology. 1970 Nov;19(5):799–807. [PMC free article] [PubMed] [Google Scholar]
  6. Kind L. S., Nilsson B. The biological activity of a ragweed arabinogalactan. I. Galactose specificity of in vitro and in vivo effects. Immunology. 1967 Nov;13(5):477–482. [PMC free article] [PubMed] [Google Scholar]
  7. Lichtenstein L. M., Gewurz H., Adkinson N. F., Jr, Shin H. S., Mergenhagen S. E. Interactions of the complement system with endotoxic lipopolysaccharide: the generation of an anaphylatoxin. Immunology. 1969 Mar;16(3):327–336. [PMC free article] [PubMed] [Google Scholar]
  8. MUNOZ J., BERGMAN R. K. MECHANISM OF ANAPHYLACTIC DEATH IN THE MOUSE. Nature. 1965 Jan 9;205:199–200. doi: 10.1038/205199b0. [DOI] [PubMed] [Google Scholar]
  9. Marcus R. L., Shin H. S., Mayer M. M. An alternate complement pathway: C-3 cleaving activity, not due to C4,2a, on endotoxic lipopolysaccharide after treatment with guinea pig serum; relation to properdin. Proc Natl Acad Sci U S A. 1971 Jun;68(6):1351–1354. doi: 10.1073/pnas.68.6.1351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Morelli R., Rosenberg L. T. Role of complement during experimental Candida infection in mice. Infect Immun. 1971 Apr;3(4):521–523. doi: 10.1128/iai.3.4.521-523.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. PILLEMER L., BLUM L., LEPOW I. H., ROSS O. A., TODD E. W., WARDLAW A. C. The properdin system and immunity. I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena. Science. 1954 Aug 20;120(3112):279–285. doi: 10.1126/science.120.3112.279. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES