Abstract
Several variables of host and parasite, relating to the establishment of the chronic Streptobacillus moniliformis-induced arthritis, were studied. Results from these studies indicated (i) that intravenous inoculation of the organism produced a progressive bacteremia and a polyarthritis, whereas subcutaneous inoculation into the top of the back foot produced an intermittent bacteremia and arthritis only in that foot, (ii) that serum-broth-grown cells were more virulent than serum-agar-grown cells, (iii) that young animals were more susceptible to infection than old, and (iv) that the organism apparently had a predilection for joints. It was also determined that the leukocyte and antibody responses of mice to infection were minimal with a slight neutrophilia and a maximum antibody titer of 1:640 detected after infection. Measurements of the effectiveness of antibody and leukocytes in prevention or resolution of infection indicated (i) that the presence of homologous antibody prior to infection prolonged the incubation period for development of the lesion, (ii) that the opsonic index was 1.2 to 1.4, and (iii) that the organism was apparently resistant to destruction by in vitro phagocytosis and actually increased in number in the presence of phagocytes. It was concluded that these represented some of the prime factors contributing to the establishment of the infection and its chronicity.
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