Abstract
The present study was undertaken to examine possible correlations between long-term protection of mice treated with polycarboxylates and infected with vaccinia virus, and the presence of subdetectable amounts of interferon in the tissues, as determined by tissue or organ resistance to replication of viruses. After a single dose of polycarboxylate, splenic resistance to virus replication could be detected. It persisted for 7 to 14 days, but no attempt was made to prove that it was due to subdetectable amounts of interferon. Whole-animal protection lasted longer than splenic resistance. Moreover, when different polycarboxylates and different virus strains were used, patterns of early protection were not correlated with those of splenic resistance. These data, as others presented earlier, suggest that, in addition to interferon, other antiviral mechanisms are stimulated by polycarboxylates.
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Selected References
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- Billiau A., Desmyter J., De Somer P. Antiviral activity of chlorite-oxidized oxyamylose, a polyacetal carboxylic acid. J Virol. 1970 Mar;5(3):321–328. doi: 10.1128/jvi.5.3.321-328.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Billiau A., Muyembe J. J., De Somer P. Mechanism of antiviral activity in vivo of polycarboxylases which induce interferon production. Nat New Biol. 1971 Aug 11;232(2):183–186. doi: 10.1038/newbio232183a0. [DOI] [PubMed] [Google Scholar]
- Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci. J Exp Med. 1971 May 1;133(5):1090–1104. doi: 10.1084/jem.133.5.1090. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Came P. E., Lieberman M., Pascale A., Shimonaski G. Antiviral activity of an interferon-inducing synthetic polymer. Proc Soc Exp Biol Med. 1969 Jun;131(2):443–446. doi: 10.3181/00379727-131-33897. [DOI] [PubMed] [Google Scholar]
- Claes P., Billiau A., De Clercq E., Desmyter J., Schonne E., Vanderhaeghe H., De Somer P. Polyacetal carboxylic acids: a new group of antiviral polyanions. J Virol. 1970 Mar;5(3):313–320. doi: 10.1128/jvi.5.3.313-320.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Clercq E., De Somer P. Effect of interferon, polyacrylin acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus. Appl Microbiol. 1968 Sep;16(9):1314–1319. doi: 10.1128/am.16.9.1314-1319.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Somer P., Billiau A. Interferon production by the spleen of rats after intravenous injection of Sindbis virus or heat-killed Escherichia coli. Arch Gesamte Virusforsch. 1966;19(2):143–154. doi: 10.1007/BF01241494. [DOI] [PubMed] [Google Scholar]
- De Somer P., De Clercq E., Billiau A., Schonne E., Claesen M. Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo. J Virol. 1968 Sep;2(9):886–893. doi: 10.1128/jvi.2.9.886-893.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fruitstone M. J., Michaels B. S., Rudloff D. A., Sigel M. M. Role of the spleen in interferon production in mice. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1008–1011. doi: 10.3181/00379727-122-31311. [DOI] [PubMed] [Google Scholar]
- Merigan T. C., Finkelstein M. S. Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. Virology. 1968 Jul;35(3):363–374. doi: 10.1016/0042-6822(68)90215-8. [DOI] [PubMed] [Google Scholar]
- Merigan T. C. Induction of circulating interferon by synthetic anionic polymers of known composition. Nature. 1967 Apr 22;214(5086):416–417. doi: 10.1038/214416a0. [DOI] [PubMed] [Google Scholar]
- Schafer T. W., Lockart R. Z., Jr Interferon required for viral resistance induced by poly I.poly C. Nature. 1970 May 2;226(5244):449–450. doi: 10.1038/226449a0. [DOI] [PubMed] [Google Scholar]