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. 1972 Jul;6(1):9–16. doi: 10.1128/iai.6.1.9-16.1972

Specific Macrophage Immunity to Vaccinia Virus: Macrophage-Virus Interaction

F R Avila 1, R M Schultz 1, W A F Tompkins 1
PMCID: PMC422482  PMID: 4564156

Abstract

Macrophage immunity to vaccinia virus was examined by measuring replication of vaccinia virus in immune and nonimmune rabbit peritoneal macrophages. Vaccinia virus multiplied in macrophages from normal rabbits but failed to replicate in macrophages from immune rabbits. The specificity of vaccinia restriction was demonstrated by the ability of myxoma virus to replicate in nonimmune and vaccinia-immune macrophages. Vaccinia virus absorbed equally well to immune and nonimmune macrophages, but only a small fraction of immune cells supported synthesis of virus antigen. Virus eclipse and infective center neutralization studies suggested that much of the virus remained at the plasma membrane of immune macrophages, even after prolonged incubation in culture. These data support our previous suggestions that macrophages may contribute to specific immunity against vaccinia virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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