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. 1972 Aug;6(2):149–155. doi: 10.1128/iai.6.2.149-155.1972

Effect of Vincristine Sulfate on Pseudomonas Infections in Monkeys

Samuel Saslaw 1, Harold N Carlisle 1, Mohammad Moheimani 1
PMCID: PMC422507  PMID: 4631913

Abstract

In rhesus monkeys, intravenous challenge with 0.6 × 1010 to 2.2 × 1010Pseudomonas aeruginosa organisms caused acute illness of 4 to 5 days' duration with spontaneous recovery in 13 of 15 monkeys; blood cultures became negative 3 to 17 days after challenge. Leukocytosis was observed in all monkeys. Intravenous or intratracheal inoculation of 2.0 to 2.5 mg of vincristine sulfate was followed by leukopenia in 4 to 5 days. Intravenous inoculation of 4.2 × 1010 to 7.8 × 1010 pyocin type 6 Pseudomonas organisms in monkeys given vincristine sulfate 4 days previously resulted in fatal infection in 11 of 14 monkeys, whereas none of four receiving Pseudomonas alone died. These studies suggest that an antimetabolite-induced leukopenia predisposes to severe Pseudomonas sepsis and that such monkeys may serve as a biological model for study of comparative efficacy of antimicrobial agents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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