Abstract
A human isolate of Cryptococcus neoformans strain CIA, which was originally obtained in 1963, produced fatal disease in mice. Postmortem examinations showed extensive central nervous system disease. After using this yeast for research for 7 years, we found that it began to produce large tumors after intraperitoneal inoculation in mice. The present study showed that the tumors consisted of large agglomerates of yeast cells, capillaries, and reticular stroma. In concomitant experiments, the same C. neoformans strain, introduced into the lungs of mice in an aerosol, produced asymptomatic infections. A definition for the term “cryptococcoma” is proposed.
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- Ajello L. Comparative ecology of respiratory mycotic disease agents. Bacteriol Rev. 1967 Mar;31(1):6–24. doi: 10.1128/br.31.1.6-24.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bulmer G. S., Sans M. D., Gunn C. M. Cryptococcus neoformans. I. Nonencapsulated mutants. J Bacteriol. 1967 Nov;94(5):1475–1479. doi: 10.1128/jb.94.5.1475-1479.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Collins D. N., Oppenheim I. A., Edwards M. R. Cryptococcosis associated with systemic lupus erythematosus. Light and electron microscopic observations on a morphologic variant. Arch Pathol. 1971 Jan;91(1):78–88. [PubMed] [Google Scholar]
- Farhi F., Bulmer G. S., Tacker J. R. Cryptococcus neoformans IV. The Not-So-Encapsulated Yeast. Infect Immun. 1970 Jun;1(6):526–531. doi: 10.1128/iai.1.6.526-531.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ishaq C. M., Bulmer G. S., Felton F. G. An evaluation of various environmental factors affecting the propagation of Cryptococcus neoformas. Mycopathol Mycol Appl. 1968 Jul 12;35(2):81–90. doi: 10.1007/BF02049570. [DOI] [PubMed] [Google Scholar]
- LITTMAN M. L., SCHNEIERSON S. S. Cryptococcus neoformans in pigeon excreta in New York City. Am J Hyg. 1959 Jan;69(1):49–59. doi: 10.1093/oxfordjournals.aje.a119980. [DOI] [PubMed] [Google Scholar]
- MIDDLEBROOK G. An apparatus for airborne infection of mice. Proc Soc Exp Biol Med. 1952 May;80(1):105–110. doi: 10.3181/00379727-80-19538. [DOI] [PubMed] [Google Scholar]
- Vanbreuseghem R. White mice sensitivity to Cryptococcus neoformans. Production of resistance against a cerebral inoculation. Ann Soc Belges Med Trop Parasitol Mycol. 1967;47(4):281–294. [PubMed] [Google Scholar]
- Werner H., Gropp A., Tonkin B. A. Generalisierte Cryptococcose mit tumorähnlichen Organmanifestationen bei einer Asiatischen Goldkatze (Profelis temmincki) Mykosen. 1970 Jan 1;13(1):25–36. [PubMed] [Google Scholar]