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. 1972 Sep;6(3):339–343. doi: 10.1128/iai.6.3.339-343.1972

Transplacental Transmission of Venezuelan Equine Encephalomyelitis Virus in Mice

R O Spertzel a, C L Crabbs a, R E Vaughn a,1
PMCID: PMC422538  PMID: 4637610

Abstract

Transplacental infection of mouse fetuses with Venezuelan equine encephalomyelitis was produced by intraperitoneal injection of dams at various stages of gestation with 103 suckling mouse intracerebral median lethal doses of an attenuated strain (TC-83). Virus inoculation, at times ranging from 6 days prior to mating to 9 days after conception, had no effect on conception rate, litter size, or survival of the newborn. Inoculation of the dam from the 10th to 13th days of gestation resulted in decreased litter size, an increase in stillbirths, and a decrease in birth-to-weaning survival. Inoculation of the dams later in gestation only decreased the birth-to-weaning survival. No evidence of morphologic abnormality was noted in any of the newborn.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen A. A., Hanson R. P. Experimental transplacental transmission of st. Louis encephalitis virus in mice. Infect Immun. 1970 Sep;2(3):320–325. doi: 10.1128/iai.2.3.320-325.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BURNS K. F. Congenital Japanese B encephalitis infection of swine. Proc Soc Exp Biol Med. 1950 Nov;75(2):621–625. doi: 10.3181/00379727-75-18285. [DOI] [PubMed] [Google Scholar]
  3. COPPS S. C., GIDDINGS L. E. Transplacental transmission of western equine encephalitis; report of a case. Pediatrics. 1959 Jul;24(1):31–33. [PubMed] [Google Scholar]
  4. Eddy G. A., Martin D. H., Reeves W. C., Johnson K. M. Field studies of an attenuated Venezuelan equine encephalomyelitis vaccine (strain TC-83). Infect Immun. 1972 Feb;5(2):160–163. doi: 10.1128/iai.5.2.160-163.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. MCKINNEY R. W., BERGE T. O., SAWYER W. D., TIGERTT W. D., CROZIER D. USE OF AN ATTENUATED STRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS FOR IMMUNIZATION IN MAN. Am J Trop Med Hyg. 1963 Jul;12:597–603. doi: 10.4269/ajtmh.1963.12.597. [DOI] [PubMed] [Google Scholar]
  6. Mims C. A. Pathogenesis of viral infections of the fetus. Prog Med Virol. 1968;10:194–237. [PubMed] [Google Scholar]
  7. SHINEFIELD H. R., TOWNSEND T. E. Transplacental transmission of western equine encephalomyelitis. J Pediatr. 1953 Jul;43(1):21–25. doi: 10.1016/s0022-3476(53)80082-x. [DOI] [PubMed] [Google Scholar]
  8. SULKIN S. E., SIMS R., ALLEN R. STUDIES OF ARTHROPOD-BORNE VIRUS INFECTIONS IN CHIROPTERA. II. EXPERIMENTS WITH JAPANESE B AND ST. LOUIS ENCEPHALITIS VIRUSES IN THE GRAVID BAT. EVIDENCE OF TRANSPLACENTAL TRANSMISSION. Am J Trop Med Hyg. 1964 May;13:475–481. [PubMed] [Google Scholar]
  9. Spertzel R. O., Kahn D. E. Safety and efficacy of an attenuated Venezuelan equine encephalomyelitis vaccine for use in Equidae. J Am Vet Med Assoc. 1971 Sep 15;159(6):731–738. [PubMed] [Google Scholar]

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