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. 1972 Nov;6(5):657–661. doi: 10.1128/iai.6.5.657-661.1972

Production and Degradation of Serogroup B Neisseria meningitidis Polysaccharide

Peter C Maloney a,1, Herman Schneider a, Brenda L Brandt a
PMCID: PMC422590  PMID: 4629201

Abstract

Polysaccharide produced from cultures of serogroups A, B, and C Neisseria meningitidis was assayed by the serogroup-specific hemagglutination inhibition (HAI) test. The polysaccharide produced by all serogroups was found to increase during the exponential phase of growth. For serogroups A and C, the HAI activity was stable during the stationary phase; for serogroup B, however, the HAI decayed rapidly. The degradation of the serogroup B polysaccharide was not caused by enzymatic degradation, but was due to acid accumulation in the culture medium. The large-molecular-size serogroup B polysaccharide was stabilized by increasing the buffering capacity of the medium, which also increased the yield of this antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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