Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1972 Nov;6(5):695–698. doi: 10.1128/iai.6.5.695-698.1972

Antiviral Action of Immune Lymphocytes in Mice Infected with Lymphocytic Choriomeningitis Virus

C A Mims a,1, R V Blanden a
PMCID: PMC422595  PMID: 4637295

Abstract

Spleen cells from immunized mice were shown to have a strong antiviral action after transfusion into infected recipients. Spleen, liver, and lung titers in recipients were reduced within 24 hr, but there was no detectable effect on brain titer. Spleen cells were active if taken 6 days after infection of donors, when no antibody was detectable. Spleen cell activity was diminished, but by no means abolished, by treatment with potent anti-theta antibody. Immune spleen cells transferred to mice infected 3 days earlier induced early signs of sickness but no change in average survival time. Normal mice injected intracerebrally with a mixture of immune spleen cells plus virus showed unusually early illness and death.

Full text

PDF
695

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci. J Exp Med. 1971 May 1;133(5):1090–1104. doi: 10.1084/jem.133.5.1090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. J Exp Med. 1970 Nov;132(5):1035–1054. doi: 10.1084/jem.132.5.1035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blanden R. V. Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J Exp Med. 1971 May 1;133(5):1074–1089. doi: 10.1084/jem.133.5.1074. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gilden D. H., Cole G. A., Nathanson N. Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers. J Exp Med. 1972 Apr 1;135(4):874–889. doi: 10.1084/jem.135.4.874. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HOTCHIN J. The biology of lymphocytic choriomeningitis infection: virus-induced immune disease. Cold Spring Harb Symp Quant Biol. 1962;27:479–499. doi: 10.1101/sqb.1962.027.001.046. [DOI] [PubMed] [Google Scholar]
  6. HOTCHIN J. The foot pad reaction of mice to lymphocytic choriomeningitis virus. Virology. 1962 May;17:214–216. doi: 10.1016/0042-6822(62)90106-x. [DOI] [PubMed] [Google Scholar]
  7. Lundstedt C. Interaction between antigenically different cells. Virus-induced cytotoxicity by immune lymphoid cells in vitro. Acta Pathol Microbiol Scand. 1969;75(1):139–152. [PubMed] [Google Scholar]
  8. MIMS C. A. Intracerebral injections and the growth of viruses in the mouse brain. Br J Exp Pathol. 1960 Feb;41:52–59. [PMC free article] [PubMed] [Google Scholar]
  9. Mims C. A., Tosolini F. A. Pathogenesis of lesions in lymphoid tissue of mice infected with lymphocytic choriomeningitis (LCM) virus. Br J Exp Pathol. 1969 Dec;50(6):584–592. [PMC free article] [PubMed] [Google Scholar]
  10. Oldstone M. B., Dixon F. J. Tissue injury in lymphocytic choriomeningitis viral infection: virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells. Virology. 1970 Dec;42(4):805–813. doi: 10.1016/0042-6822(70)90330-2. [DOI] [PubMed] [Google Scholar]
  11. Tosolini F. A., Mims C. A. Effect of murine strain and viral strain on the pathogenesis of lymphocytic choriomeningitis infection and a study of footpad responses. J Infect Dis. 1971 Feb;123(2):134–144. doi: 10.1093/infdis/123.2.134. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES