Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1973 Jan;7(1):111–116. doi: 10.1128/iai.7.1.111-116.1973

Detection of Coronavirus Strain 692 by Immune Electron Microscopy

Albert Z Kapikian 1, Harvey D James Jr 1, Sara J Kelly 1, Annie L Vaughn 1
PMCID: PMC422645  PMID: 16558070

Abstract

Utilization of the technique of immune electron microscopy has enabled the detection of a coronavirus in organ culture harvests derived from a washing from an adult with an acute upper respiratory tract illness; convalescent serum was the source of specific antibody.

Full text

PDF
111

Images in this article

113Image
on p.113
114Image
on p.114

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALMEIDA J., CINADER B., HOWATSON A. THE STRUCTURE OF ANTIGEN-ANTIBODY COMPLEXES. A STUDY BY ELECTRON MICROSCOPY. J Exp Med. 1963 Sep 1;118:327–340. doi: 10.1084/jem.118.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Almeida J. D., Goffe A. P. Antibody to wart virus in human sera demonstrated by electron microscopy and precipitin tests. Lancet. 1965 Dec 11;2(7424):1205–1207. doi: 10.1016/s0140-6736(65)90633-1. [DOI] [PubMed] [Google Scholar]
  3. Almeida J. D., Laurence G. D. Heated and unheated antiserum on rubella virus. Morphological effect. Am J Dis Child. 1969 Jul;118(1):101–106. doi: 10.1001/archpedi.1969.02100040103017. [DOI] [PubMed] [Google Scholar]
  4. Almeida J. D., Rubenstein D., Stott E. J. New antigen-antibody system in Australia-antigen-positive hepatitis. Lancet. 1971 Dec 4;2(7736):1225–1227. doi: 10.1016/s0140-6736(71)90543-5. [DOI] [PubMed] [Google Scholar]
  5. Almeida J. D., Waterson A. P. The morphology of virus-antibody interaction. Adv Virus Res. 1969;15:307–338. doi: 10.1016/S0065-3527(08)60878-7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BORSOS T., DOURMASHKIN R. R., HUMPHREY J. H. LESIONS IN ERYTHROCYTE MEMBRANES CAUSED BY IMMUNE HAEMOLYSIS. Nature. 1964 Apr 18;202:251–252. doi: 10.1038/202251a0. [DOI] [PubMed] [Google Scholar]
  7. Berry D. M., Almeida J. D. The morphological and biological effects of various antisera on avian infectious bronchitis virus. J Gen Virol. 1968 Jul;3(1):97–102. doi: 10.1099/0022-1317-3-1-97. [DOI] [PubMed] [Google Scholar]
  8. Bradburne A. F. Antigenic relationships amongst coronaviruses. Arch Gesamte Virusforsch. 1970;31(3):352–364. doi: 10.1007/BF01253769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bradburne A. F. Sensitivity of L132 cells to some "new" respiratory viruses. Nature. 1969 Jan 4;221(5175):85–86. doi: 10.1038/221085a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bradburne A. F., Tyrrell D. A. The propagation of "coronaviruses" in tissue-culture. Arch Gesamte Virusforsch. 1969;28(2):133–150. doi: 10.1007/BF01249379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Brucková M., McIntosh K., Kapikian A. Z., Chanock R. M. The adaptation of two human coronavirus strains (OC38 and OC43) to growth in cell monolayers. Proc Soc Exp Biol Med. 1970 Nov;135(2):431–435. doi: 10.3181/00379727-135-35068. [DOI] [PubMed] [Google Scholar]
  12. Cavallaro J. J., Monto A. S. Community-wide outbreak of infection with a 229E-like coronavirus in Tecumseh, Michigan. J Infect Dis. 1970 Oct;122(4):272–279. doi: 10.1093/infdis/122.4.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ferris A. A. Antigen in infectious hepatitis. Br Med Bull. 1972 May;28(2):131–133. doi: 10.1093/oxfordjournals.bmb.a070911. [DOI] [PubMed] [Google Scholar]
  14. HOORN B., TYRRELL D. A. ON THE GROWTH OF CERTAIN "NEWER" RESPIRATORY VIRUSES IN ORGAN CULTURES. Br J Exp Pathol. 1965 Apr;46:109–118. [PMC free article] [PubMed] [Google Scholar]
  15. Hamre D., Procknow J. J. A new virus isolated from the human respiratory tract. Proc Soc Exp Biol Med. 1966 Jan;121(1):190–193. doi: 10.3181/00379727-121-30734. [DOI] [PubMed] [Google Scholar]
  16. Hendley J. O., Fishburne H. B., Gwaltney J. M., Jr Coronavirus infections in working adults. Eight-year study with 229 E and OC 43. Am Rev Respir Dis. 1972 May;105(5):805–811. doi: 10.1164/arrd.1972.105.5.805. [DOI] [PubMed] [Google Scholar]
  17. Kapikian A. Z., Almeida J. D., Stott E. J. Immune electron microscopy of rhinoviruses. J Virol. 1972 Jul;10(1):142–146. doi: 10.1128/jvi.10.1.142-146.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kapikian A. Z., James H. D., Jr, Kelly S. J., Dees J. H., Turner H. C., McIntosh K., Kim H. W., Parrott R. H., Vincent M. M., Chanock R. M. Isolation from man of "avian infectious bronchitis virus-like" viruses (coronaviruses) similar to 229E virus, with some epidemiological observations. J Infect Dis. 1969 Mar;119(3):282–290. doi: 10.1093/infdis/119.3.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Kapikian A. Z., James H. D., Jr, Kelly S. J., King L. M., Vaughn A. L., Chanock R. M. Hemadsorption by coronavirus strain OC43. Proc Soc Exp Biol Med. 1972 Jan;139(1):179–186. doi: 10.3181/00379727-139-36105. [DOI] [PubMed] [Google Scholar]
  20. Kapikian A. Z., Mufson M. A., James H. D., Jr, Kalica A. R., Bloom H. H., Chanock R. M. Characterization of two newly recognized rhinovirus serotypes of human origin. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1155–1162. doi: 10.3181/00379727-122-31350. [DOI] [PubMed] [Google Scholar]
  21. Kaye H. S., Marsh H. B., Dowdle W. R. Seroepidemiologic survey of coronavirus (strain OC 43) related infections in a children's population. Am J Epidemiol. 1971 Jul;94(1):43–49. doi: 10.1093/oxfordjournals.aje.a121293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. LEIBOVITZ A. THE GROWTH AND MAINTENANCE OF TISSUE-CELL CULTURES IN FREE GAS EXCHANGE WITH THE ATMOSPHERE. Am J Hyg. 1963 Sep;78:173–180. doi: 10.1093/oxfordjournals.aje.a120336. [DOI] [PubMed] [Google Scholar]
  23. McIntosh K., Becker W. B., Chanock R. M. Growth in suckling-mouse brain of "IBV-like" viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2268–2273. doi: 10.1073/pnas.58.6.2268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. McIntosh K., Dees J. H., Becker W. B., Kapikian A. Z., Chanock R. M. Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease. Proc Natl Acad Sci U S A. 1967 Apr;57(4):933–940. doi: 10.1073/pnas.57.4.933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. McIntosh K., Kapikian A. Z., Hardison K. A., Hartley J. W., Chanock R. M. Antigenic relationships among the coronaviruses of man and between human and animal coronaviruses. J Immunol. 1969 May;102(5):1109–1118. [PubMed] [Google Scholar]
  26. McIntosh K., Kapikian A. Z., Turner H. C., Hartley J. W., Parrott R. H., Chanock R. M. Seroepidemiologic studies of coronavirus infection in adults and children. Am J Epidemiol. 1970 Jun;91(6):585–592. doi: 10.1093/oxfordjournals.aje.a121171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Oshiro L. S., Schieble J. H., Lennette E. H. Electron microscopic studies of coronavirus. J Gen Virol. 1971 Aug;12(2):161–168. doi: 10.1099/0022-1317-12-2-161. [DOI] [PubMed] [Google Scholar]
  28. Schaaff D. M., Boswell J., Mufson M. A. Viral and mycoplasmal infections in minor respiratory illnesses and nonstreptococcal pharyngitis. A search for coronaviruses using fetal trachea organ cultures. Am Rev Respir Dis. 1971 Jul;104(1):41–51. doi: 10.1164/arrd.1971.104.1.41. [DOI] [PubMed] [Google Scholar]
  29. TYRRELL D. A., BYNOE M. L. CULTIVATION OF A NOVEL TYPE OF COMMON-COLD VIRUS IN ORGAN CULTURES. Br Med J. 1965 Jun 5;1(5448):1467–1470. doi: 10.1136/bmj.1.5448.1467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Tyrrell D. A., Bynoe M. L., Hoorn B. Cultivation of "difficult" viruses from patients with common colds. Br Med J. 1968 Mar 9;1(5592):606–610. doi: 10.1136/bmj.1.5592.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Tyrrell D. A. Hunting common cold viruses by some new methods. J Infect Dis. 1970 May;121(5):561–571. doi: 10.1093/infdis/121.5.561. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES