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. 1973 Feb;7(2):298–304. doi: 10.1128/iai.7.2.298-304.1973

An Antiphagocytic Factor Associated with Group E Streptococcus 1

Raymond A Daynes a,2, Charles H Armstrong a
PMCID: PMC422673  PMID: 4572614

Abstract

Group E streptococci (GES) grown in Tryptose phosphate broth (TPB) were highly susceptible to nonspecific phagocytosis by porcine leukocytes, whereas GES grown in serum-supplemented TPB (STPB) were resistant to nonspecific phagocytosis. It was concluded that serum supplementation induced the elaboration of an antiphagocytic factor (APF). The APF was distinct from the group-specific and type-specific polysaccharide antigens, and it was destroyed by trypsin. Electron photomicrographs revealed that GES grown in STPB possessed a fimbriated surface component similar to M protein-positive stains of group A streptococcus. The surface component was absent when GES were propagated in unfortified TPB. The APF was neutralized specifically by sera from swine immune to streptococcic lymphadenitis (SLS), a disease caused by GES. It was hypothesized that the APF was associated with the pathogenicity of GES and that it was involved in the induction of protective immunity to SLS.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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