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. 1973 Mar;7(3):403–408. doi: 10.1128/iai.7.3.403-408.1973

Effects of Promethazine-Hydrochloride on Human Polymorphonuclear Leukocytes

Lawrence R DeChatelet 1, Diane Qualliotine-Mann 1, Ronald Caldwell 1, Charles E McCall 1, John P Gusdon 1
PMCID: PMC422692  PMID: 4713692

Abstract

Promethazine hydrochloride at a concentration of 0.033 mg/ml has pronounced effects on leukocyte metabolism and function. The drug inhibits the phagocytosis-induced increases in O2 consumption and hexose monophosphate shunt activity. Associated with these effects is an inhibition of the iodination of zymosan particles and an inhibition of bacterial killing by the cell. At least two mechanisms appear to be involved. Many of the effects can be explained by an inhibition of phagocytosis, but promethazine also inhibits the decarboxylation of amino acids and iodide fixation in a cell-free system, indicating a specific effect on metabolism. These results may partially account for the action of the drug in ameliorating the effects of erythroblastosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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