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. 1973 Mar;7(3):468–472. doi: 10.1128/iai.7.3.468-472.1973

Effect in Mice of Injection of Viable Candida albicans and a Cell-Free Sonic Extract on Circulating Platelets

Ian A Holder 1, Paul Nathan 1
PMCID: PMC422701  PMID: 4576682

Abstract

The ability of intravenously injected Candida albicans to cause thrombocytopenia and clotting disorders was tested. Mice injected in this manner showed a decrease in circulating platelets and a shortening of clotting time within hours after challenge. Treatment with heparin changed the death distribution pattern, but did not increase overall long-term survival. A cell-free sonic extract prepared from viable C. albicans cells was shown to cause aggregation of platelets in vitro, and injection of the cell-free extract into mice caused a decrease in circulating platelets similar to that observed when viable organisms were injected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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