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. 1973 May;7(5):764–770. doi: 10.1128/iai.7.5.764-770.1973

Relationship of BCG-Induced Pulmonary Delayed Hypersensitivity to Accelerated Granuloma Formation in Rabbit Lungs: Effect of Cortisone Acetate

Vernon L Moore a,1, Quentin N Myrvik a
PMCID: PMC422758  PMID: 4797184

Abstract

The role of local pulmonary delayed hypersensitivity in accelerated pulmonary granuloma formation was investigated using cortisone acetate, an immunosuppressive drug that appears to preferentially eliminate committed lymphocytes at appropriate doses. Data are presented showing that cortisone acetate suppressed local pulmonary delayed hypersensitivity at the time of and subsequent to challenge with BCG. Furthermore, cortisone damage appeared to involve primarily committed lymphocyte populations since the defect was repairable with sensitized spleen cells, an unlikely source of macrophage precursors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coe J. E., Feldman J. D., Lee S. Immunologic competence of thoracic duct cells. I. Delayed hypersensitivity. J Exp Med. 1966 Feb 1;123(2):267–281. doi: 10.1084/jem.123.2.267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Domingo E. O., Warren K. S. The inhibition of granuloma formation around Schistosoma mansoni eggs. 3. Heterologous antilymphocyte serum. Am J Pathol. 1968 Mar;52(3):613–631. [PMC free article] [PubMed] [Google Scholar]
  3. Domingo E. O., Warren K. S. The inhibition of granuloma formation around Schistosoma mansoni eggs. II. Thymectomy. Am J Pathol. 1967 Nov;51(5):757–767. [PMC free article] [PubMed] [Google Scholar]
  4. Galindo B., Heise E. R., Myrvik Q. N. Migration inhibition response of mononuclear cells mediating granulomatous inflammation. Ser Haematol. 1970;3(2):145–159. [PubMed] [Google Scholar]
  5. Galindo B., Myrvik Q. N. Migratory response of granulomatous alveolar cells from BCG-sensitized rabbits. J Immunol. 1970 Jul;105(1):227–237. [PubMed] [Google Scholar]
  6. Henney C. S., Waldman R. H. Cell-mediated immunity shown by lymphocytes from the respiratory tract. Science. 1970 Aug 14;169(3946):696–697. doi: 10.1126/science.169.3946.696. [DOI] [PubMed] [Google Scholar]
  7. KAWATA H., MYRVIK Q. N., LEAKE E. S. DISSOCIATION OF TUBERCULIN HYPERSENSITIVITY AS MEDIATOR FOR AN ACCELERATED PULMONARY GRANULOMATOUS RESPONSE IN RABBITS. J Immunol. 1964 Sep;93:433–438. [PubMed] [Google Scholar]
  8. Katz D. H., Paul W. E., Goidl E. A., Benacerraf B. Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med. 1971 Feb 1;133(2):169–186. doi: 10.1084/jem.133.2.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Koster F. T., McGregor D. D., Mackaness G. B. The mediator of cellular immunity. II. Migration of immunologically committed lymphocytes into inflammatory exudates. J Exp Med. 1971 Feb 1;133(2):400–409. doi: 10.1084/jem.133.2.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Koster F. T., McGregor D. D. The mediator of cellular immunity. 3. Lymphocyte traffic from the blood into the inflamed peritoneal cavity. J Exp Med. 1971 Apr 1;133(4):864–876. doi: 10.1084/jem.133.4.864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Leake E. S., Myrvik Q. N. Changes in morphology and in lysozyme content of free alveolar cells after the intravenous injection of killed BCG in oil. J Reticuloendothel Soc. 1968 Feb;5(1):33–53. [PubMed] [Google Scholar]
  12. Lubaroff D. M., Waksman B. H. Bone marrow as a source of cells in reactions of cellular hypersensitivity. I. Passive transfer of tuberculin sensitivity in syngeneic systems. J Exp Med. 1968 Dec 1;128(6):1425–1435. doi: 10.1084/jem.128.6.1425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lubaroff D. M., Waksman B. H. Bone marrow as source of cells in reactions of cellular hypersensitivity. II. Identification of allogeneic or hybrid cells by immunofluorescence in passively transferred tuberculin reactions. J Exp Med. 1968 Dec 1;128(6):1437–1447. doi: 10.1084/jem.128.6.1437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MYRVIK Q. N., LEAKE E. S., OSHIMA S. A study of macrophages and epitheloid-like cells from granulomatous (BCG-induced) lungs of rabbits. J Immunol. 1962 Nov;89:745–751. [PubMed] [Google Scholar]
  15. MYRVIK Q., LEAKE E. S., FARISS B. Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity. J Immunol. 1961 Feb;86:128–132. [PubMed] [Google Scholar]
  16. Mackaness G. B. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med. 1969 May 1;129(5):973–992. doi: 10.1084/jem.129.5.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. McGregor D. D., Koster F. T., Mackaness G. B. The mediator of cellular immunity. I. The life-span and circulation dynamics of the immunologically committed lymphocyte. J Exp Med. 1971 Feb 1;133(2):389–399. doi: 10.1084/jem.133.2.389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Moore V. L., Myrvik Q. N. Effect of antimacrophage serum on dermal tuberculin sensitivity and allergic pulmonary granuloma formation in rabbits. Infect Immun. 1970 Dec;2(6):810–814. doi: 10.1128/iai.2.6.810-814.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. North R. J. The action of cortisone acetate on cell-mediated immunity to infection. Suppression of host cell proliferation and alteration of cellular composition of infective foci. J Exp Med. 1971 Dec 1;134(6):1485–1500. doi: 10.1084/jem.134.6.1485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. North R. J. The action of cortisone acetate on cell-mediated immunity to infection: histogenesis of the lymphoid cell response and selective elimination of committed lymphocytes. Cell Immunol. 1972 Mar;3(3):501–515. doi: 10.1016/0008-8749(72)90255-9. [DOI] [PubMed] [Google Scholar]
  21. Schlossman S. F., Levin H. A., Rocklin R. E., David J. R. The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs. J Exp Med. 1971 Sep 1;134(3 Pt 1):741–750. doi: 10.1084/jem.134.3.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Warren K. S., Domingo E. O., Cowan R. B. Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity. Am J Pathol. 1967 Nov;51(5):735–756. [PMC free article] [PubMed] [Google Scholar]
  23. Yamamoto K., Anacker R. L. Macrophage Migration Inhibition Studies with Cells from Mice Vaccinated with Cell Walls of Mycobacterium bovis BCG: Characterization of the Experimental System. Infect Immun. 1970 Jun;1(6):587–594. doi: 10.1128/iai.1.6.587-594.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]

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