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. 1973 May;7(5):777–780. doi: 10.1128/iai.7.5.777-780.1973

Comparison of Strains of BCG I. Antigenic Analysis and Tuberculin Reactivity

Sotiros D Chaparas 1, Sally R Hedrick 1
PMCID: PMC422760  PMID: 4202960

Abstract

At least 10 of 11 demonstrable antigens in unheated culture filtrates of 12 vaccine strains of BCG were shared as determined in a reference antigen-antibody immunoelectrophoresis system. Filtrates from each of the BCG strains gave equivalent skin test reactions in homologously and heterologously sensitized guinea pigs. By these immunological parameters, the 12 BCG strains were remarkably similar.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHAPARAS S. D., BAER H. THE IMMUNOLOGY AND CHEMISTRY OF TUBERCULIN. II. CHROMATOGRAPHY WITH SEPHADEX OF THE NONDIALYZABLE TUBERCULIN-ACTIVE CONSTITUENTS OF BCG CULTURE FILTRATE. Am Rev Respir Dis. 1964 Jan;89:41–48. doi: 10.1164/arrd.1964.89.1.41. [DOI] [PubMed] [Google Scholar]
  2. JESPERSEN A., BENTZON M. W. THE ACQUIRED RESISTANCE TO TUBERCULOSIS INDUCED BY BCG VACCINE ASSAYED BY A QUANTITATIVE METHOD ON RED MICE. CLETHRIONOMYS G. GLAREOLUS SCHREB. II. VACCINATION EFFECT OF BCG STRAINS STRONGLY OR MODERATELY VIRULENT FOR HAMSTERS. Acta Tuberc Pneumol Scand. 1964;44:276–289. [PubMed] [Google Scholar]
  3. Janicki B. W., Chaparas S. D., Daniel T. M., Kubica G. P., Wright G. L., Yee G. S. A reference system for antigens of Mycobacterium tuberculosis. Am Rev Respir Dis. 1971 Oct;104(4):602–604. doi: 10.1164/arrd.1971.104.4.602. [DOI] [PubMed] [Google Scholar]
  4. LIND A. Serological studies of mycobacteria by means of diffusion-in-gel techniques. 3. A difference in precipitinogenic content found in substrains of BCG. Int Arch Allergy Appl Immunol. 1960;17:1–9. doi: 10.1159/000229107. [DOI] [PubMed] [Google Scholar]
  5. Mackaness G. B. Resistance to intracellular infection. J Infect Dis. 1971 Apr;123(4):439–445. doi: 10.1093/infdis/123.4.439. [DOI] [PubMed] [Google Scholar]
  6. Magnusson M. A comparative study of Mycobacterium gastri and Mycobacterium kansasii by delayed type skin reactions in guinea pigs. Am Rev Respir Dis. 1971 Sep;104(3):377–384. doi: 10.1164/arrd.1971.104.3.377. [DOI] [PubMed] [Google Scholar]
  7. Pearson J. W., Pearson G. R., Gibson W. T., Chermann J. C., Chirigos M. A. Combined chemoimmunostimulation therapy against murine leukemia. Cancer Res. 1972 May;32(5):904–907. [PubMed] [Google Scholar]

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