Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1973 Jul;8(1):80–82. doi: 10.1128/iai.8.1.80-82.1973

Labile Inhibitor of Lymphocyte Transformation in Plasma from a Patient with Subacute Sclerosing Panencephalitis

Jeffrey Allen 1,2, Joost Oppenheim 1,2, Jacob A Brody 1,2, Joseph Miller 1,2
PMCID: PMC422813  PMID: 4718925

Abstract

A thermolabile inhibitory factor of mitogen-induced lymphocyte transformation was observed in the fresh plasma of one patient in stage 3 of subacute sclerosing panencephalitis (SSPE) and not in three other patients in various stages of the disease. Thus, its relevance to SSPE is not clear. The plasma factor was removed by adsorption onto human and animal cells and polystyrene beads, and it was found in the 7S globulin fraction of the effluent from gel permeation chromatography.

Full text

PDF
80

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blaese R. M., Oppenheim J. J., Seeger R. C., Waldmann T. A. Lymphocyte-macrophage interaction in antigen induced in vitro lymphocyte transformation in patients with the Wiskott-Aldrich syndrome and other diseases with anergy. Cell Immunol. 1972 Jul;4(3):228–242. doi: 10.1016/0008-8749(72)90027-5. [DOI] [PubMed] [Google Scholar]
  2. Burnet F. M. Measles as an index of immunological function. Lancet. 1968 Sep 14;2(7568):610–613. doi: 10.1016/s0140-6736(68)90701-0. [DOI] [PubMed] [Google Scholar]
  3. Gatti R. A. Serum inhibitors of lymphocyte responses. Lancet. 1971 Jun 26;1(7713):1351–1352. doi: 10.1016/s0140-6736(71)91906-4. [DOI] [PubMed] [Google Scholar]
  4. Gerson K. L., Haslam R. H. Subtle immunologic abnormalities in four boys with subacute sclerosing panencephalitis. N Engl J Med. 1971 Jul 8;285(2):78–82. doi: 10.1056/NEJM197107082850203. [DOI] [PubMed] [Google Scholar]
  5. Horta-Barbosa L., Hamilton R., Wittig B., Fuccillo D. A., Sever J. L., Vernon M. L. Subacute sclerosing panencephalitis: isolation of suppressed measles virus from lymph node biopsies. Science. 1971 Aug 27;173(3999):840–841. doi: 10.1126/science.173.3999.840. [DOI] [PubMed] [Google Scholar]
  6. Horta-Barbosa L., Krebs H., Ley A., Chen T. C., Gilkeson M. R., Sever J. L. Progressive increase in cerebrospinal fluid measles antibody levels in subacute sclerosing panencephalitis. Pediatrics. 1971 Apr;47(4):782–783. [PubMed] [Google Scholar]
  7. Payne F. E., Baublis J. V., Itabashi H. H. Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. N Engl J Med. 1969 Sep 11;281(11):585–589. doi: 10.1056/NEJM196909112811103. [DOI] [PubMed] [Google Scholar]
  8. Silk M. R. The effect of uremic plasma on lymphocyte transformation. Invest Urol. 1967 Sep;5(2):195–199. [PubMed] [Google Scholar]
  9. Silk M. Effect of plasma from patients with carcinoma on in vitro lymphocyte transformation. Cancer. 1967 Dec;20(12):2088–2089. doi: 10.1002/1097-0142(196712)20:12<2088::aid-cncr2820201205>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  10. Zweiman B. In vitro effects of measles virus on proliferating human lymphocytes. J Immunol. 1971 May;106(5):1154–1158. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES