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. 1973 Aug;8(2):173–177. doi: 10.1128/iai.8.2.173-177.1973

Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin

E T Rietschel 1,2, Y B Kim 1,2, D W Watson 1,2, C Galanos 1,2, O Lüderitz 1,2, O Westphal 1,2
PMCID: PMC422829  PMID: 4725697

Abstract

The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A·BSA and lipid A·HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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