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. 1973 Aug;8(2):278–290. doi: 10.1128/iai.8.2.278-290.1973

Production of Haemophilus influenzae b Meningitis in Infant Rats by Intraperitoneal Inoculation

Arnold L Smith 1,2, David H Smith 1,2, Damon R Averill Jr 1,2, Joseph Marino 1,2, E Richard Moxon 1,2
PMCID: PMC422844  PMID: 4542033

Abstract

Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.

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Selected References

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