Abstract
Sprague-Dawley rats have a marked age-related susceptibility to Haemophilus influenzae type b that does not correlate with serum bactericidal activity. Eighty percent of 5-day-old animals that survive to 48 h after an intraperitoneal inoculation of a mean lethal dose of bacteria have histologically documented meningitis. Animals surviving the inoculations as infants manifest cerebral dysfunction as adults. This model should facilitate experimental study of bacterial meningitis.
Full text
PDF












Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson P., Johnston R. B., Jr, Smith D. H. Human serum activities against Hemophilus influenzae, type b. J Clin Invest. 1972 Jan;51(1):31–38. doi: 10.1172/JCI106793. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Glass B., Collipp P. J., Waldman M. A. Viral and bacterial meningitis. N Y State J Med. 1971 Sep 15;71(8):2182–2186. [PubMed] [Google Scholar]
- HAGGERTY R. J., ZIAI M. ACUTE BACTERIAL MENINGITIS. Adv Pediatr. 1964;13:129–181. [PubMed] [Google Scholar]
- HAMBURGER M., CLARK K. L., BIEHL J. P., JERVEY L. P., Jr Studies in experimental meningitis in Rhesus monkeys. I. The pathogenic effect of various bacteria recovered from human cases. J Infect Dis. 1955 Jul-Aug;97(1):39–47. doi: 10.1093/infdis/97.1.39. [DOI] [PubMed] [Google Scholar]
- HARTER D. H., PETERSDORF R. G. A consideration of the pathogenesis of bacterial meningitis: review of experimental and clinical studies. Yale J Biol Med. 1960 Feb;32:280–309. [PMC free article] [PubMed] [Google Scholar]
- KENNEDY P. C., BIBERSTEIN E. L., HOWARTH J. A., FRAZIER L. M., DUNGWORTH D. L. Infectious meningo-encephalitis in cattle, caused by a haemophilus-like organism. Am J Vet Res. 1960 Mar;21:403–409. [PubMed] [Google Scholar]
- KISSANE J. M., ROBINS E. The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system. J Biol Chem. 1958 Jul;233(1):184–188. [PubMed] [Google Scholar]
- NYHAN W. L., RICHARDSON F. Complications of meningitis. Annu Rev Med. 1963;14:243–260. doi: 10.1146/annurev.me.14.020163.001331. [DOI] [PubMed] [Google Scholar]
- PETERSDORF R. G., LUTTRELL C. N. Studies on the pathogenesis of meningitis. I. Intrathecal infection. J Clin Invest. 1962 Feb;41:311–319. doi: 10.1172/JCI104484. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH J. F., LANDING B. H. Mechanisms of brain damage in H. influenzae meningitis. J Neuropathol Exp Neurol. 1960 Apr;19:248–265. doi: 10.1097/00005072-196004000-00006. [DOI] [PubMed] [Google Scholar]
- SWARTZ M. N., DODGE P. R. BACTERIAL MENINGITIS--A REVIEW OF SELECTED ASPECTS. 1. GENERAL CLINICAL FEATURES, SPECIAL PROBLEMS AND UNUSUAL MENINGEAL REACTIONS MIMICKING BACTERIAL MENINGITIS. N Engl J Med. 1965 Apr 15;272:779–CONTD. doi: 10.1056/NEJM196504152721506. [DOI] [PubMed] [Google Scholar]
- ZAMENHOF S., BURSZTYN H., RICH K., ZAMENHOF P. J. THE DETERMINATION OF DEOXYRIBONUCLEIC ACID AND OF CELL NUMBER IN BRAIN. J Neurochem. 1964 Jul;11:505–509. doi: 10.1111/j.1471-4159.1964.tb07499.x. [DOI] [PubMed] [Google Scholar]