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. 1973 Oct;8(4):510–518. doi: 10.1128/iai.8.4.510-518.1973

Role of Cell-Mediated Immunity in the Recovery of Cattle from Primary and Recurrent Infections with Infectious Bovine Rhinotracheitis Virus

D H Davies a,1, L E Carmichael a
PMCID: PMC422884  PMID: 4355136

Abstract

When cattle infected with infectious bovine rhinotracheitis virus (IBRV) were treated 3 months later with a synthetic corticosteroid, consistent recrudescence of the infection was observed. Suppression of cell-mediated immunity, as measured by lymphocyte transformation responses, could be demonstrated at the time of recrudescence. Treatment with adrenocorticotropic hormone and trigeminal neurotomy also resulted in recrudescence of IBRV, but immunosuppression was not detected in these animals. The detection of specific, antigen-induced, lymphocyte transformation responses at the time of recovery from both primary and recurrent infections suggests that cell-mediated immunity may be important in determining the duration and severity of the recurrent infection. However, immunosuppression may not be the direct mechanism of recrudescence.

Lesions were not observed in untreated animals, and virus could not be detected in either tissues or secretions. However, both lesions and virus were found consistently after corticosteroid treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMSTRONG J. A., PEREIRA H. G., ANDREWES C. H. Observations on the virus of infectious bovine rhinotracheitis, and its affinity with the Herpesvirus group. Virology. 1961 Jun;14:276–285. doi: 10.1016/0042-6822(61)90204-5. [DOI] [PubMed] [Google Scholar]
  2. Byerly J. L., Dawe D. L. Delayed hypersensitivity reactions in Marek's disease virus-infected chickens. Am J Vet Res. 1972 Nov;33(11):2267–2273. [PubMed] [Google Scholar]
  3. CRUICKSHANK J. G., BERRY D. M. MORPHOLOGY OF INFECTIOUS BOVINE RHINOTRACHEITIS VIRUS. Virology. 1965 Mar;25:481–481. doi: 10.1016/0042-6822(65)90072-3. [DOI] [PubMed] [Google Scholar]
  4. David J. R., David R. R. Cellular hypersensitivity and immunity. Inhibition of macrophage migration and the lymphocyte mediators. Prog Allergy. 1972;16:300–449. [PubMed] [Google Scholar]
  5. Davies A. J. The thymus and the cellular basis of immunity. Transplant Rev. 1969;1:43–91. doi: 10.1111/j.1600-065x.1969.tb00136.x. [DOI] [PubMed] [Google Scholar]
  6. Gerber P., Lucas S. J. In vitro stimulation of human lymphocytes by Epstein-Barr virus. Cell Immunol. 1972 Oct;5(2):318–324. doi: 10.1016/0008-8749(72)90057-3. [DOI] [PubMed] [Google Scholar]
  7. House J. A., Baker J. A. Bovine herpesvirus IBR-IPV. The antibody virus neutralization reaction. Cornell Vet. 1971 Apr;61(2):320–335. [PubMed] [Google Scholar]
  8. JAWETZ E., COLEMAN V., ALLENDE M. F. Studies on herpes simplex virus. II. A soluble antigen of herpes virus possessing skin-reactive properties. J Immunol. 1951 Sep;67(3):197–205. [PubMed] [Google Scholar]
  9. Kaufman H. E., Brown D. C., Ellison E. M. Recurrent herpes in the rabbit and man. Science. 1967 Jun 23;156(3782):1628–1629. doi: 10.1126/science.156.3782.1628. [DOI] [PubMed] [Google Scholar]
  10. Merigan T. C., Stevens D. A. Viral infections in man associated with acquired immunological deficiency states. Fed Proc. 1971 Nov-Dec;30(6):1858–1864. [PubMed] [Google Scholar]
  11. Moorhead J. W., Claman H. N. Thymus-derived lymphocytes and hydrocortisone: identification of subsets of theta-bearing cells and redistribution to bone marrow. Cell Immunol. 1972 Sep;5(1):74–86. doi: 10.1016/0008-8749(72)90085-8. [DOI] [PubMed] [Google Scholar]
  12. Nahmias A. J., Hirsch M. S., Kramer J. H., Murphy F. A. Effect of antithymocyte serum on herpesvirus hominis (type 1) infection in adult mice. Proc Soc Exp Biol Med. 1969 Nov;132(2):696–698. doi: 10.3181/00379727-132-34290. [DOI] [PubMed] [Google Scholar]
  13. North R. J. The action of cortisone acetate on cell-mediated immunity to infection: histogenesis of the lymphoid cell response and selective elimination of committed lymphocytes. Cell Immunol. 1972 Mar;3(3):501–515. doi: 10.1016/0008-8749(72)90255-9. [DOI] [PubMed] [Google Scholar]
  14. Oates C. M., Bissenden J. F., Maini R. N., Payne L. N., Dumonde D. C. Thymus and bursa dependence of lymphocyte mitogenic factor in the chicken. Nat New Biol. 1972 Oct 4;239(92):137–139. doi: 10.1038/newbio239137a0. [DOI] [PubMed] [Google Scholar]
  15. PAINE T. F., Jr LATENT HERPES SIMPLEX INFECTION IN MAN. Bacteriol Rev. 1964 Dec;28:472–479. doi: 10.1128/br.28.4.472-479.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Phillips S. M., Carpenter C. B., Merrill J. P. Cellular immunity in the mouse. II. Correlation of in vivo and in vitro phenomena. Cell Immunol. 1972 Oct;5(2):249–263. doi: 10.1016/0008-8749(72)90051-2. [DOI] [PubMed] [Google Scholar]
  17. Piguet P. F., Vassalli P. Thymus-independent (B) cell proliferation in spleen cell cultures of mouse radiation chimeras stimulated by phytohemagglutinin or allogeneic cells. J Exp Med. 1972 Oct 1;136(4):962–967. doi: 10.1084/jem.136.4.962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rodey G. E., Good R. A. The in vitro response to phytohemagglutinin of lyphoid cells from normal and neonatally thymectomized adult mice. Int Arch Allergy Appl Immunol. 1969;36(4):399–407. doi: 10.1159/000230760. [DOI] [PubMed] [Google Scholar]
  19. Rosenberg G. L., Farber P. A., Notkins A. L. In vitro stimulation of sensitized lymphocytes by herpes simplex virus and vaccinia virus. Proc Natl Acad Sci U S A. 1972 Mar;69(3):756–760. doi: 10.1073/pnas.69.3.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sheffy B. E., Davies D. H. Reactivation of a bovine herpesvirus after corticosteroid treatment. Proc Soc Exp Biol Med. 1972 Jul;140(3):974–976. doi: 10.3181/00379727-140-36592. [DOI] [PubMed] [Google Scholar]
  21. Spencer E. S., Andersen H. K. Clinically evident, non-terminal infections with herpesviruses and the wart virus in immunosuppressed renal allograft recipients. Br Med J. 1970 Aug 1;3(5717):251–254. doi: 10.1136/bmj.3.5717.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Tormey D. C., Fudenberg H. H., Kamin R. M. Effect of prednisolone on synthesis of DNA and RNA by human lymphocytes in vitro. Nature. 1967 Jan 21;213(5073):281–282. doi: 10.1038/213281a0. [DOI] [PubMed] [Google Scholar]
  23. Wilton J. M., Ivanyi L., Lehner T. Cell-mediated immunity in Herpesvirus hominis infections. Br Med J. 1972 Mar 18;1(5802):723–726. doi: 10.1136/bmj.1.5802.723. [DOI] [PMC free article] [PubMed] [Google Scholar]

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