The article by Taylor et al provided very limited data comparing use of analgesics and rates of nonunion.1 It is pretty drastic to conclude that “patients should not be denied NSAIDs [nonsteroidal anti-inflammatory drugs] for short-term pain relief.”1 In terms of fracture healing there is evidence in rodent studies that NSAIDs can slow healing.2–4 A review article by Boursinos et al advised caution in using NSAIDs in patients with fractures.5 As inflammation is the first step in the healing process, and given the range of choice of analgesics, there is no particular reason to recommend NSAIDs after a fracture.
Footnotes
Competing interests
None declared
References
- 1.Taylor IC, Lindblad AJ, Kolber MR. Fracture healing and NSAIDs. Can Fam Physician. 2014;60:817. (Eng), e429 (Fr). [PMC free article] [PubMed] [Google Scholar]
- 2.Li J, Waugh LJ, Hui SL, Burr DB, Warden SJ. Low-intensity pulsed ultrasound and nonsteroidal anti-inflammatory drugs have opposing effects during stress fracture repair. J Ortho Res. 2007;25(12):1559–67. doi: 10.1002/jor.20461. [DOI] [PubMed] [Google Scholar]
- 3.Murnaghan M, Li G, Marsh DR. Nonsteroidal anti-inflammatory drug-induced fracture nonunion: an inhibition of angiogenesis? J Bone Joint Surg Am. 2006;88(Suppl 3):140–7. doi: 10.2106/JBJS.F.00454. [DOI] [PubMed] [Google Scholar]
- 4.Brown KM, Saunders MM, Kirsch T, Donahue HJ, Reid JS. Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg Am. 2004;86-A(1):116–23. doi: 10.2106/00004623-200401000-00017. [DOI] [PubMed] [Google Scholar]
- 5.Boursinos LA, Karachalios T, Poultsides L, Malizos KN. Do steroids, conventional nonsteroidal anti-inflammatory drugs and selective Cox-2 inhibitors adversely affect fracture healing? J Musculoskelet Neuronal Interact. 2009;9(1):44–52. [PubMed] [Google Scholar]
