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. 1973 Nov;8(5):708–714. doi: 10.1128/iai.8.5.708-714.1973

Resistance of Mice to Infection with Friend Disease Virus After Subcutaneous Injection of Friend Virus and Friend Spleen Cells

C L Larson 1,2, R N Ushijima 1,2, S K Kasuga 1,2, R E Baker 1,2, M B Baker 1,2
PMCID: PMC422916  PMID: 4748944

Abstract

Swiss mice injected subcutaneously with suspensions of spleen cells or an extract of spleens from mice infected with Friend virus develop resistance to subsequent intravenous inoculation of Friend virus. A single injection of either Friend virus or Friend cells induces resistance. Immunized mice display resistance when challenged 6 months after immunization and survive for at least 20 weeks after infection. Neutralization tests indicate that serum, but not lymphoid cells of resistant animals, can neutralize Friend virus. In vitro neutralization tests indicate that residence of virus within the peritoneal cavity of immune mice for 1 h sharply reduces the infective titer of the virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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