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. 1973 Dec;8(6):860–867. doi: 10.1128/iai.8.6.860-867.1973

Analogy of Mycobacterium marinum Disease to Mycobacterium leprae Infection in Footpads of Mice

Herman Ng 1, Peter L Jacobsen 1, Louis Levy 1
PMCID: PMC422941  PMID: 4594116

Abstract

Because it appeared likely that the disease process that follows inoculation of footpads of mice with Mycobacterium marinum might serve as a useful model of mouse footpad infection with M. leprae for immunological studies. an attempt was made to establish an analogy between the two processes. As a second objective, the adequacy of measurements of mouse footpad thickness as an index of the total number of M. marinum and of the number of viable M. marinum was determined. The evolution of M. marinum disease in the footpads of BALB/c mice was observed, and the influences of mouse age and sex and of inoculum size were measured. Mice were challenged with M. marinum in one footpad at several intervals after inoculation of the contralateral hind footpad with the same organism. In all of these experiments, mouse footpad thickness was noted to parallel multiplication of M. marinum during the phase of increasing footpad swelling. Cessation of bacterial multiplication was noted to occur just before maximal swelling had been achieved, and was followed by rapid loss of viable M. marinum. The total number of organisms and mouse footpad thickness decreased only slowly and incompletely. Analogy between M. marinum disease and M. leprae infection of the mouse footpad was established by the self-limited nature of both processes, and by similar patterns of protection against homologous and heterologous challenge conferred by the two processes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CLARK H. F., SHEPARD C. C. EFFECT OF ENVIRONMENTAL TEMPERATURES ON INFECTION WITH MYCOBACTERIUM MARINUM (BALNEI) OF MICE AND A NUMBER OF POIKILOTHERMIC SPECIES. J Bacteriol. 1963 Nov;86:1057–1069. doi: 10.1128/jb.86.5.1057-1069.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Evans M. J., Newton H. E., Levy L. Early response of mouse foot pads to Mycobacterium laprae. Infect Immun. 1973 Jan;7(1):76–85. doi: 10.1128/iai.7.1.76-85.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FENNER F. Homologous and heterologous immunity in infections of mice with Mycobacterium ulcerans and Mycobacterium balnei. Am Rev Tuberc. 1957 Jul;76(1):76–89. doi: 10.1164/artpd.1957.76.1.76. [DOI] [PubMed] [Google Scholar]
  4. FENNER F. The pathogenic behavior of Mycobacterium ulcerans and Mycobacterium balnei in the mouse and the developing chick embryo. Am Rev Tuberc. 1956 May;73(5):650–673. doi: 10.1164/artpd.1956.73.5.650. [DOI] [PubMed] [Google Scholar]
  5. Gaugas J. M. Enhancing effect of antilymphocytic globulin on human leprosy infection in thymectomized mice. Nature. 1968 Dec 21;220(5173):1246–1248. doi: 10.1038/2201246a0. [DOI] [PubMed] [Google Scholar]
  6. Rees R. J. Enhanced susceptibility of thymectomized and irradiated mice to infection with Mycobacterium leprae. Nature. 1966 Aug 6;211(5049):657–658. doi: 10.1038/211657a0. [DOI] [PubMed] [Google Scholar]
  7. SHEPARD C. C., MCRAE D. H. MYCOBACTERIUM LEPRAE IN MICE: MINIMAL INFECTIOUS DOSE, RELATIONSHIP BETWEEN STAINING QUALITY AND INFECTIVITY, AND EFFECT OF CORTISONE. J Bacteriol. 1965 Feb;89:365–372. doi: 10.1128/jb.89.2.365-372.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. SHEPARD C. C. VACCINATION AGAINST EXPERIMENTAL INFECTION WITH MYCOBACTERIUM LEPRAE. Am J Epidemiol. 1965 Mar;81:150–163. doi: 10.1093/oxfordjournals.aje.a120504. [DOI] [PubMed] [Google Scholar]
  9. Shepard C. C. A comparison of the effectiveness of two freeze-dried BCG vaccines against Mycobacterium leprae in mice. Bull World Health Organ. 1968;38(1):135–140. [PMC free article] [PubMed] [Google Scholar]
  10. Shepard C. C., Habas J. A. Relation of infection to tissue temperature in mice infected with Mycobacterium marinum and Mycobacterium leprae. J Bacteriol. 1967 Mar;93(3):790–796. doi: 10.1128/jb.93.3.790-796.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shepard C. C., McRae D. H. A method for counting acid-fast bacteria. Int J Lepr Other Mycobact Dis. 1968 Jan-Mar;36(1):78–82. [PubMed] [Google Scholar]
  12. Shepard C. C., Redus M. A. Effect of immunosuppressive drugs on infection in mice by M. marinum (balnei), M. tuberculosis and M. leprae. Int J Lepr Other Mycobact Dis. 1967 Jul-Sep;35(3):348–354. [PubMed] [Google Scholar]
  13. Shepard C. C. Vaccination against human leprosy bacillus infections of mice: protection by BCG given during the incubation period. J Immunol. 1966 Feb;96(2):279–283. [PubMed] [Google Scholar]

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