Abstract
Intracerebral inoculation of 4-day-old rats with lymphocytic choriomeningitis virus (E-350 strain) produced a nonfatal, acute, severe, and permanent cerebellar necrosis with minimal histological evidence of inflammation. Virus persisted in the brain at high titers for 30 to 40 days and was finally cleared about 120 days after infection. Rabbit anti-rat lymphoid serum prevented cerebellar necrosis, and brain virus titers were higher than in control animals receiving normal rabbit serum. Thus, the immune response which clearly is responsible for the cerebellar lesion also plays a role in the gradual suppression of infection.
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- Cole G. A., Gilden D. H., Monjan A. A., Nathanson N. Lymphocytic choriomeningitis virus: pathogenesis of acute central nervous system disease. Fed Proc. 1971 Nov-Dec;30(6):1831–1841. [PubMed] [Google Scholar]
- Cole G. A., Nathanson N., Prendergast R. A. Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. Nature. 1972 Aug 11;238(5363):335–337. doi: 10.1038/238335a0. [DOI] [PubMed] [Google Scholar]
- Gilden D. H., Cole G. A., Nathanson N. Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers. J Exp Med. 1972 Apr 1;135(4):874–889. doi: 10.1084/jem.135.4.874. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOTCHIN J. The biology of lymphocytic choriomeningitis infection: virus-induced immune disease. Cold Spring Harb Symp Quant Biol. 1962;27:479–499. doi: 10.1101/sqb.1962.027.001.046. [DOI] [PubMed] [Google Scholar]
- Levey R. H., Medawar P. B. Nature and mode of action of antilymphocytic antiserum. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130–1137. doi: 10.1073/pnas.56.4.1130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MITCHISON N. A. INDUCTION OF IMMUNOLOGICAL PARALYSIS IN TWO ZONES OF DOSAGE. Proc R Soc Lond B Biol Sci. 1964 Dec 15;161:275–292. doi: 10.1098/rspb.1964.0093. [DOI] [PubMed] [Google Scholar]
- Monjan A. A., Cole G. A., Gilden D. H., Nathanson N. Pathogenesis of cerebellar hypoplasia produced by lymphocytic choriomeningitis virus infection of neonatal rats. 1. Evolution of disease following infection at 4 days of age. J Neuropathol Exp Neurol. 1973 Jan;32(1):110–124. doi: 10.1097/00005072-197301000-00007. [DOI] [PubMed] [Google Scholar]