Abstract
The lung tissue of six dogs with ehrlichiosis and two control dogs was examined with the electron microscope. Mononuclear cells containing inclusions (morulae) of Ehrlichia canis were adhered at one or more sites to the luminal surfaces of endothelial cells of arterioles or capillaries by way of interdigitations or areas of adherence, or an endothelial cell-bound mononuclear cell was chained to another parasitized or nonparasitized mononuclear cell in the lumen. The bifurcation of arterioles was the most common site at which mononuclear cells clung to the endothelium. Cell-free bodies (morulae), enclosed by a single membrane, were present in the lumens of arterioles. Such cell-free bodies were swollen and vesiculated as compared with intracytoplasmic inclusions (morulae) in mononuclear cells.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Hildebrandt P. K., Conroy J. D., McKee A. E., Nyindo M. B., Huxsoll D. L. Ultrastructure of Ehrlichia canis. Infect Immun. 1973 Feb;7(2):265–271. doi: 10.1128/iai.7.2.265-271.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huxsoll D. L., Amyx H. L., Hemelt I. E., Hildebrandt P. K., Nims R. M., Gochenour W. S., Jr Laboratory studies of tropical canine pancytopenia. Exp Parasitol. 1972 Feb;31(1):53–59. doi: 10.1016/0014-4894(72)90046-x. [DOI] [PubMed] [Google Scholar]
- Huxsoll D. L., Hildebrandt P. K., Nims R. M., Amyx H. L., Ferguson J. A. Epizootiology of tropical canine pancytopenia. J Wildl Dis. 1970 Oct;6(4):220–225. doi: 10.7589/0090-3558-6.4.220. [DOI] [PubMed] [Google Scholar]
- Jones D. B. The morphology of acid mucosubstances in leukocytic sticking to endothelium in acute inflammation. Lab Invest. 1970 Dec;23(6):606–611. [PubMed] [Google Scholar]
- MARCHESI V. T. SOME ELECTRON MICROSCOPIC OBSERVATIONS ON INTERACTIONS BETWEEN LEUKOCYTES, PLATELETS, AND ENDOTHELIAL CELLS IN ACUTE INFLAMMATION. Ann N Y Acad Sci. 1964 Aug 27;116:774–788. doi: 10.1111/j.1749-6632.1964.tb52545.x. [DOI] [PubMed] [Google Scholar]
- REYNOLDS E. S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. doi: 10.1083/jcb.17.1.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Simpson C. F. Structure of Ehrlichia canis in blood monocytes of a dog. Am J Vet Res. 1972 Dec;33(12):2451–2454. [PubMed] [Google Scholar]
- Walker J. S., Rundquist J. D., Taylor R., Wilson B. L., Andrews M. R., Barck J., Hogge A. L., Jr, Huxsoll D. L., Hildebrandt P. K., Nims R. M. Clinical and clinicopathologic findings in tropical canine pancytopenia. J Am Vet Med Assoc. 1970 Jul 1;157(1):43–55. [PubMed] [Google Scholar]