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. 1974 Oct;10(4):747–749. doi: 10.1128/iai.10.4.747-749.1974

Cholera Toxoid Boosts Serum Escherichia coli Antitoxin in Humans

D R Nalin 1, A Al-Mahmud 1, G Curlin 1, A Ahmed 1, J Peterson 1
PMCID: PMC423016  PMID: 4609909

Abstract

Sera from individuals vaccinated with a cholera toxoid were tested to determine if sera with significant titers of cholera antitoxin could neutralize Escherichia coli thermolabile enterotoxin. Individuals who responded to immunization with significant increases in serum cholera antitoxin titers also showed increases in serum E. coli enterotoxin-neutralizing capacity. These findings suggested the possibility that the cholera toxoid vaccine may be useful in preventing disease caused by E. coli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Evans D. G., Evans D. J., Jr, Pierce N. F. Differences in the response of rabbit small intestine to heat-labile and heat-stable enterotoxins of Escherichia coli. Infect Immun. 1973 Jun;7(6):873–880. doi: 10.1128/iai.7.6.873-880.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Evans D. J., Jr, Evans D. G., Gorbach S. L. Production of vascular permeability factor by enterotoxigenic Escherichia coli isolated from man. Infect Immun. 1973 Nov;8(5):725–730. doi: 10.1128/iai.8.5.725-730.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hochstein H. D., Feeley J. C., DeWitt W. E. Titration of cholera antitoxin in human sera by microhemagglutination with formalinized erythrocytes. Appl Microbiol. 1970 May;19(5):742–745. doi: 10.1128/am.19.5.742-745.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. MCINTYRE O. R., FEELEY J. C. PASSIVE SERUM PROTECTION OF THE INFANT RABBIT AGAINST EXPERIMENTAL CHOLERA. J Infect Dis. 1964 Dec;114:468–475. doi: 10.1093/infdis/114.5.468. [DOI] [PubMed] [Google Scholar]
  5. Nalin D. R., Richardson S. H., Bhattacharjee A. K. Diarrhoea resembling cholera induced by Escherichia coli culture filtrate. Lancet. 1973 Apr 21;1(7808):885–885. doi: 10.1016/s0140-6736(73)91453-0. [DOI] [PubMed] [Google Scholar]
  6. Nalin D. R., Richardson S. H. Diarrhea resembling cholera induced by Escherichia coli culture filtrate. Lancet. 1973 Mar 24;1(7804):677–678. doi: 10.1016/s0140-6736(73)92255-1. [DOI] [PubMed] [Google Scholar]

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