Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1974 Oct;10(4):757–761. doi: 10.1128/iai.10.4.757-761.1974

Cell-Mediated Immunity in Humans During Viral Infection: Dermal Hypersensitivity and In Vitro Lymphocyte Proliferation During Mild Viral Respiratory Infections

Carol A Kauffman 1, Calvin C Linnemann Jr 1, James S Tan 1, Gilbert M Schiff 1, John P Phair 1
PMCID: PMC423018  PMID: 4372179

Abstract

In vitro lymphocyte proliferation in response to phytohemagglutinin and streptokinase-streptodornase and delayed dermal hypersensitivity to several antigens were assessed in patients with mild viral upper respiratory infections. The response to phytohemagglutinin in 18 patients was not diminished during the viral infection. Deoxyribonucleic acid synthesis induced by streptokinase-streptodornase remained unaffected by the viral illness in five patients, and skin test reactivity was not depressed during the viral infection. Thus, it appeared that localized viral upper respiratory infections were not associated with suppression of systemic cell-mediated immunity.

Full text

PDF
757

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENTZON J. W. The effect of certain infectious diseases on tuberculin allergy. Tubercle. 1953 Feb;34(2):34–41. doi: 10.1016/s0041-3879(53)80013-9. [DOI] [PubMed] [Google Scholar]
  2. BRODY J. A., MCALISTER R. DEPRESSION OF TUBERCULIN SENSITIVITY FOLLOWING MEASLES VACCINATION. Am Rev Respir Dis. 1964 Oct;90:607–611. doi: 10.1164/arrd.1964.90.4.607. [DOI] [PubMed] [Google Scholar]
  3. Belsey M. A. Tuberculosis and varicella infections in children. Am J Dis Child. 1967 Apr;113(4):444–448. doi: 10.1001/archpedi.1967.02090190090007. [DOI] [PubMed] [Google Scholar]
  4. David J. R. Lymphocyte mediators and cellular hypersensitivity. N Engl J Med. 1973 Jan 18;288(3):143–149. doi: 10.1056/NEJM197301182880311. [DOI] [PubMed] [Google Scholar]
  5. Fireman P., Friday G., Kumate J. Effect of measles vaccine on immunologic responsiveness. Pediatrics. 1969 Feb;43(2):264–272. [PubMed] [Google Scholar]
  6. Gresser I., Lang D. J. Relationships between viruses and leucocytes. Prog Med Virol. 1966;8:62–130. [PubMed] [Google Scholar]
  7. Kauffman C. A., Phair J. P., Linnemann C. C., Jr, Schiff G. M. Cell-mediated immunity in humans during viral infection. I. Effect of rubella on dermal hypersensitivity, phytohemagglutinin response, and T lymphocyte numbers. Infect Immun. 1974 Jul;10(1):212–215. doi: 10.1128/iai.10.1.212-215.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kupers T. A., Petrich J. M., Holloway A. W., St Geme J. W., Jr Depression of tuberculin delayed hypersensitivity by live attenuated mumps virus. J Pediatr. 1970 May;76(5):716–721. doi: 10.1016/s0022-3476(70)80290-6. [DOI] [PubMed] [Google Scholar]
  9. Lehmann N. I., Gust I. D. Viraemia in influenza. A report of two cases. Med J Aust. 1971 Dec 4;2(23):1166–1169. doi: 10.5694/j.1326-5377.1971.tb92768.x. [DOI] [PubMed] [Google Scholar]
  10. NAFICY K. HUMAN INFLUENZA INFECTION WITH PROVED VIREMIA. REPORT OF A CASE. N Engl J Med. 1963 Oct 31;269:964–966. doi: 10.1056/NEJM196310312691807. [DOI] [PubMed] [Google Scholar]
  11. Notkins A. L., Mergenhagen S. E., Howard R. J. Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970;24:525–538. doi: 10.1146/annurev.mi.24.100170.002521. [DOI] [PubMed] [Google Scholar]
  12. Olson G. B., Dent P. B., Rawls W. E., South M. A., Montgomery J. R., Melnick J. L., Good R. A. Abnormalities of in vitro lymphocyte responses during rubella virus infections. J Exp Med. 1968 Jul 1;128(1):47–68. doi: 10.1084/jem.128.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Reed W. P., Olds J. W., Kisch A. L. Decreased skin-test reactivity associated with influenza. J Infect Dis. 1972 Apr;125(4):398–402. doi: 10.1093/infdis/125.4.398. [DOI] [PubMed] [Google Scholar]
  14. STARR S., BERKOVICH S. EFFECTS OF MEASLES, GAMMA-GLOBULIN-MODIFIED MEASLES AND VACCINE MEASLES ON THE TUBERCULIN TEST. N Engl J Med. 1964 Feb 20;270:386–391. doi: 10.1056/NEJM196402202700802. [DOI] [PubMed] [Google Scholar]
  15. Salaman M. H. Immunodepression by mammalian viruses and plasmodia. Proc R Soc Med. 1970 Jan;63(1):11–15. [PMC free article] [PubMed] [Google Scholar]
  16. Stanley E. D., Jackson G. G. Viremia in Asian influenza. Trans Assoc Am Physicians. 1966;79:376–387. [PubMed] [Google Scholar]
  17. Thomas J. W., Clements D., Naiman S. C. Lymphocyte transformation by phytohemagglutinin: IV. In acute upper respiratory infections. Can Med Assoc J. 1968 Sep 14;99(10):467–468. [PMC free article] [PubMed] [Google Scholar]
  18. White R. G., Boyd J. F. The effect of measles on the thymus and other lymphoid tissues. Clin Exp Immunol. 1973 Mar;13(3):343–357. [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES