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. 1974 Nov;10(5):1018–1022. doi: 10.1128/iai.10.5.1018-1022.1974

Cell-Mediated Immune Responses of Preleukemic AKR Mice

Robert J Martig 1, Jack L Tribble 1
PMCID: PMC423054  PMID: 16558082

Abstract

Splenic lymphocytes from preleukemic AKR mice are capable of participating in various cell-mediated immune responses. Spleen cells from AKR mice aged 1 to 10 months produced a significant graft-versus-host reaction when injected into 8-day-old AKR × C57Bl/6 F1 hybrids. Splenic lymphocytes from similarly aged mice were also capable of responding to allogenic stimulation in a mixed lymphocyte reaction. AKR mice aged 1 to 10 months developed a contact sensitivity response to picryl chloride. It was concluded that mice of this high-leukemic strain have a competent cell-mediated immune system and there is no depression of immunity during the preleukemic period.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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