Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1974 Nov;10(5):1029–1033. doi: 10.1128/iai.10.5.1029-1033.1974

Enhancement of Primary Antigen-Specific Resistance in Infant Mice with Divinyl Ether-Maleic Anhydride

J Y Richmond 1, C H Campbell 1
PMCID: PMC423056  PMID: 16558084

Abstract

The early response of infant mice to foot-and-mouth disease viral antigens, measured by greater resistance and increased serum-neutralizing antibody, was enhanced by divinyl ether-maleic anhydride (DVE/MA). Preparations of known antigen concentration were used to study various parameters influencing this enhancement. Resistance and antibody levels were increased when DVE/MA was administered with aqueous or oil-emulsified antigens, whether given separately or mixed with the antigens, but was dependent on the dose and route of the DVE/MA and antigen. Enhanced resistance developed rapidly, was antigen-specific, and may have been related to the level of neutralizing antibody.

Full text

PDF
1029

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Billiau A., Muyembe J. J., De Somer P. Mechanism of antiviral activity in vivo of polycarboxylases which induce interferon production. Nat New Biol. 1971 Aug 11;232(2):183–186. doi: 10.1038/newbio232183a0. [DOI] [PubMed] [Google Scholar]
  2. Braun W., Nakano M. Antibody formation: stimulation by polyadenylic and polycytidylic acids. Science. 1967 Aug 18;157(3790):819–821. doi: 10.1126/science.157.3790.819. [DOI] [PubMed] [Google Scholar]
  3. Braun W., Regelson W., Yajima Y., Ishizuka M. Stimulation of antibody formation by pyran copolymer. Proc Soc Exp Biol Med. 1970 Jan;133(1):171–175. doi: 10.3181/00379727-133-34433. [DOI] [PubMed] [Google Scholar]
  4. Campbell C. H. Influence of litter size, age, variation, and selective breeding of mice on susceptibility to foot-and-mouth disease virus. Am J Vet Res. 1968 Mar;29(3):685–691. [PubMed] [Google Scholar]
  5. Campbell C. H., Richmond J. Y. Enhancement, by two carboxylic acid interferon inducers of resistance stimulated in mice by foot-and-mouth disease vaccine. Infect Immun. 1973 Feb;7(2):199–204. doi: 10.1128/iai.7.2.199-204.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chester T. J., de Clercq E., Merigan T. C. Effect of Separate and Combined Injections of Poly rI: Poly rC and Endotoxin on Reticulo-endothelial Activity, Interferon, and Antibody Production in the Mouse. Infect Immun. 1971 Apr;3(4):516–520. doi: 10.1128/iai.3.4.516-520.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cone R. E., Johnson A. G. Regulation of the immune system by synthetic polynucleotides. 3. Action on antigen-reactive cells of thymic origin. J Exp Med. 1971 Mar 1;133(3):665–676. doi: 10.1084/jem.133.3.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Diamantstein T., Rühl H., Vogt W., Bochert G. Stimulation of B-cells by dextran sulphate in vitro. Immunology. 1973 Oct;25(4):743–747. [PMC free article] [PubMed] [Google Scholar]
  9. Diamantstein T., Wagner B., Beyse I., Odenwald M. V. Zum Mechanismus der Stimulierung der humoralen Antikörperbildung durch Polyanionen. Z Klin Chem Klin Biochem. 1970 Nov;8(6):632–636. [PubMed] [Google Scholar]
  10. Graves J. H., McKercher P. D., Callis J. J. Foot-and-mouth disease vaccine: influence of the vaccine virus subtype on neutralizing antibody and resistance to disease. Am J Vet Res. 1972 Apr;33(4):765–768. [PubMed] [Google Scholar]
  11. Merigan T. C., Finkelstein M. S. Interferon-stimulating and in vivo antiviral effects of various synthetic anionic polymers. Virology. 1968 Jul;35(3):363–374. doi: 10.1016/0042-6822(68)90215-8. [DOI] [PubMed] [Google Scholar]
  12. Morahan P. S., Regelson W., Munson A. E. Pyran and polyribonucleotides: differences in biological activities. Antimicrob Agents Chemother. 1972 Jul;2(1):16–22. doi: 10.1128/aac.2.1.16. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Munson A. E., Regelson W., Lawrence W., Jr, Wooles W. R. Biphasic response of the reticuloendothelial system (RES) induced by pyran copolymer. J Reticuloendothel Soc. 1970 Mar;7(3):375–385. [PubMed] [Google Scholar]
  14. POLATNICK J., BACHRACH H. L. PRODUCTION AND PURIFICATION OF MILLIGRAM AMOUNTS OF FOOT-AND-MOUTH DISEASE VIRUS FROM BABY HAMSTER KIDNEY CELL CULTURES. Appl Microbiol. 1964 Jul;12:368–373. doi: 10.1128/am.12.4.368-373.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pindak F. F., Schmidt J. P., Giron D. J., Allen P. T. Interferon levels and resistance to viral infection associated with selected interferon inducers. Proc Soc Exp Biol Med. 1971 Oct;138(1):317–321. doi: 10.3181/00379727-138-35887. [DOI] [PubMed] [Google Scholar]
  16. Richmond J. Y., Campbell C. H. Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: effect on adsorption and multiplication in mouse tissues. Arch Gesamte Virusforsch. 1972;36(3):232–239. doi: 10.1007/BF01249854. [DOI] [PubMed] [Google Scholar]
  17. Richmond J. Y. Mouse Resistance Against Foot-and-Mouth Disease Virus Induced by Injections of Pyran. Infect Immun. 1971 Feb;3(2):249–253. doi: 10.1128/iai.3.2.249-253.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Wagner G. G., Card J. L., Cowan K. M. Immunochemical studies of foot-and-mouth disease. VII. Characterization of foot-and-mouth disease virus concentrated by polyethylene glycol precipitation. Arch Gesamte Virusforsch. 1970;30(4):343–352. doi: 10.1007/BF01258364. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES