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. 1974 Nov;10(5):1040–1043. doi: 10.1128/iai.10.5.1040-1043.1974

Development and Passive Transfer of Immunity to Gonococcal Infection in Guinea Pigs

R W Scales 1, S J Kraus 1
PMCID: PMC423058  PMID: 16558086

Abstract

Gonococcal infections of relatively long duration were produced in guinea pigs with minimal infective doses ranging from 101 to 102 colony-forming units. After spontaneous eradication and upon rechallenge with ≥108 gonococcal colony-forming units, guinea pigs were refractory to infection. Serum from these guinea pigs was bactericidal in vitro and protected virgin guinea pigs from in vivo challenge. The 7S peak, but not the 19S peak, from gel filtered immune serum demonstrated both bactericidal and passive protective properties. In vitro bactericidal activity of whole immune serum and its 7S peak was abolished after heating at 56 C for 30 min. The in vivo protective ability of the 7S peak was not abolished after heating.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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