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. 1974 Nov;10(5):1072–1076. doi: 10.1128/iai.10.5.1072-1076.1974

Persistent Infection of Mice with the Virus of Lymphocytic Choriomeningitis: Virus-Specific Immunological Tolerance

Josef Cihak 1, Fritz Lehmann-Grube 1
PMCID: PMC423064  PMID: 16558092

Abstract

Lymphocytic choriomeningitis (LCM) virus-infected culture cells as targets were markedly reduced in numbers when incubated in vitro with spleen cells from LCM virus-immune mice, even if the cells were taken months after a subcutaneous immunizing infection of the donor animal. Spleen cells from mice persistently infected with LCM virus had no effect on target cells. Also, mitomycin C-blocked LCM virus-infected culture cells stimulated the incorporation of radiolabeled thymidine into spleen cells from LCM virus-immune mice. No stimulation was observed with spleen cells from LCM virus carrier mice. It was concluded that cell-mediated immunity directed against LCM virion surface antigen(s) is absent in LCM virus carrier mice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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