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. 1974 Dec;10(6):1195–1201. doi: 10.1128/iai.10.6.1195-1201.1974

Protection Against Gram-Negative Infections with Antiserum to Lipid A from Salmonella minnesota R595

Noel A Mullan 1, Peter M Newsome 1, Peter G Cunnington 1, Geoff H Palmer 1, Margaret E Wilson 1
PMCID: PMC423086  PMID: 4611919

Abstract

The ability of antisera to lipid A, induced in rabbits by immunization with lipid A complexed to various carriers, to protect mice against gram-negative infection and to inhibit the fluid loss caused by an enteropathogenic strain of Escherichia coli in the piglet ligated gut was investigated. No significant protection was obtained in either case, although passive hemolysis and quantitative precipitation tests showed the presence of antilipid A antibodies in the sera. Fluorescent antibody studies suggest that the lipid A is in a cryptic position on the surface of smooth strains of gram-negative bacteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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