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. 1974 Dec;10(6):1202–1206. doi: 10.1128/iai.10.6.1202-1206.1974

Antiviral Activity of an Ether-Extracted Nonviable Preparation of Brucella abortus

JS Youngner 1, G Keleti 1, D S Feingold 1
PMCID: PMC423087  PMID: 4373393

Abstract

Extraction of living Brucella abortus (strain 456) with aqueous ether yielded a nonviable, insoluble residue (Bru-Pel). When injected into mice, Bru-Pel was an effective, nontoxic interferon stimulus. Mice pretreated with Bru-Pel were protected against challenge with otherwise lethal doses of Semliki Forest virus. Significant protection was afforded when Bru-Pel was given as many as 7 days before virus challenge. Evidence is presented dealing with the complex nature of Bru-Pel and with the possibility that the antiviral activity of Bru-Pel may be associated not only with the production of interferon, but with a general increase in the level of nonspecific resistance in animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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