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Infection and Immunity logoLink to Infection and Immunity
. 1974 Dec;10(6):1241–1249. doi: 10.1128/iai.10.6.1241-1249.1974

Intracellular and Extracellular Degranulation of Human Polymorphonuclear Azurophil and Specific Granules Induced by Immune Complexes

Mary S Leffell 1, John K Spitznagel 1
PMCID: PMC423094  PMID: 4215759

Abstract

The nature of the phagocytic stimulus determines the degree of degranulation. Specifically, immune complexes induced more degranulation than did antigen or antibody alone. The release of constituents from the two granule classes represented independent phenomena. Relatively more of the specific granule proteins were released into the medium during phagocytosis, whereas more of the azurophil proteins were associated with the phagosomes.

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Selected References

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