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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Hypertension. 2014 Sep 22;64(6):1260–1265. doi: 10.1161/HYPERTENSIONAHA.114.03406

Figure 2.

Figure 2

Contractile responses to (A) phenylephrine, an α-adrenoreceptor agonist, (n=4 each group) or (B) U46619, a thromboxane A2 mimetic, in first order branches of the pulmonary artery obtained from 20 week old TWIK-2 KO and WT mice. * p=0.04 compared to 10−6 M U46619 in WT, n=8 for each group. C: Contractile responses to U46619 in first order branches of the pulmonary artery from 20 week old WT and TWIK-2 KO mice in the presence of 1 uM (10−6 moles/liter) and 10 uM (10−5 moles/liter) Y27632, an inhibitor of Rho-kinase. * p≤ 0.002 compared to all other groups, ** p=0.038 compared to KO with 1 uM Y27632.