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. 2013 Jul 30;2(3):520–532. doi: 10.3390/pathogens2030520

Figure 2.

Figure 2

Histopathology and PrPres immunostaining. Spongiosis (A–D) and PrPres deposition (E–H) in frontal cortex in primates infected with cattle-adapted TME (A, E), L-BSE (B, F), classical BSE (C, G) or raccoon TME (D, H) (original magnification x200 for spongiosis and x400 for PrPres staining). Immunostaining of PrPres was performed with 3F4 monoclonal anti-PrP antibody after proteinase K treatment as previously described [21]. No staining was observed in the brain of control healthy primates (data not shown) under these conditions.