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. 1986 Oct;78(4):899–905. doi: 10.1172/JCI112678

Preweaning food intake influences the adiposity of young adult baboons.

D S Lewis, H A Bertrand, C A McMahan, H C McGill Jr, K D Carey, E J Masoro
PMCID: PMC423712  PMID: 3760191

Abstract

The hypothesis that preweaning nutrition influences adult fat cell number and adiposity was tested in baboons. Newborn baboons were fed Similac formulas with caloric densities of 40.5 kcal (underfed), 67.5 kcal (fed normally), and 94.5 kcal (overfed) per 100 g formula. From weaning (16 wk) until necropsy at 5 yr of age all baboons were fed the same diet. At necropsy, fat cell number and fat cell size in 10 fat depots were measured. Female baboons overfed as infants had markedly greater fat depot mass, primarily because of fat cell hypertrophy, than normally fed or underfed females. Overfed male baboons had a greater fat mass in 4 of 10 depots compared with males underfed or fed normally as infants. Underfeeding did not affect body weight, nor adipose mass of either sex. The results show that infant food intake does not have a major influence on the fat cell number of young adult baboons.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Björntorp P., Gustafson A., Persson B. Adipose tissue fat cell size and number in relation to metabolism in endogenous hypertriglyceridemia. Acta Med Scand. 1971 Nov;190(5):363–367. doi: 10.1111/j.0954-6820.1971.tb07444.x. [DOI] [PubMed] [Google Scholar]
  2. Björntorp P., Jonsson A., Berchtold P. Adipose tissue cellularity in maturity onset diabetes mellitus. Acta Med Scand. 1972 Jan-Feb;191(1-2):129–132. [PubMed] [Google Scholar]
  3. Björntorp P., Karlsson M., Pettersson P. Expansion of adipose tissue storage capacity at different ages in rats. Metabolism. 1982 Apr;31(4):366–373. doi: 10.1016/0026-0495(82)90112-3. [DOI] [PubMed] [Google Scholar]
  4. Brasel J. A. Changes in body composition during adolescence. Curr Concepts Nutr. 1982;11:13–18. [PubMed] [Google Scholar]
  5. Bray G. A. Measurement of subcutaneous fat cells from obese patients. Ann Intern Med. 1970 Oct;73(4):565–569. doi: 10.7326/0003-4819-73-4-565. [DOI] [PubMed] [Google Scholar]
  6. Brook C. G. Evidence for a sensitive period in adipose-cell replication in man. Lancet. 1972 Sep 23;2(7778):624–627. doi: 10.1016/s0140-6736(72)93017-6. [DOI] [PubMed] [Google Scholar]
  7. Brook C. G., Lloyd J. K., Wolf O. H. Relation between age of onset of obesity and size and number of adipose cells. Br Med J. 1972 Apr 1;2(5804):25–27. doi: 10.1136/bmj.2.5804.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Charney E., Goodman H. C., McBride M., Lyon B., Pratt R. Childhood antecedents of adult obesity. Do chubby infants become obese adults? N Engl J Med. 1976 Jul 1;295(1):6–9. doi: 10.1056/NEJM197607012950102. [DOI] [PubMed] [Google Scholar]
  9. Czajka-Narins D. M., Hirsch J. Supplementary feeding during the preweaning period. Effect on carcass composition and adipose tissue cellularity of the rat. Biol Neonate. 1974;25(3-4):176–185. doi: 10.1159/000240690. [DOI] [PubMed] [Google Scholar]
  10. Di Girolamo M., Mendlinger S., Fertig J. W. A simple method to determine fat cell size and number in four mammalian species. Am J Physiol. 1971 Sep;221(3):850–858. doi: 10.1152/ajplegacy.1971.221.3.850. [DOI] [PubMed] [Google Scholar]
  11. Eid E. E. Follow-up study of physical growth of children who had excessive weight gain in first six months of life. Br Med J. 1970 Apr 11;2(5701):74–76. doi: 10.1136/bmj.2.5701.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Faust I. M., Johnson P. R., Stern J. S., Hirsch J. Diet-induced adipocyte number increase in adult rats: a new model of obesity. Am J Physiol. 1978 Sep;235(3):E279–E286. doi: 10.1152/ajpendo.1978.235.3.E279. [DOI] [PubMed] [Google Scholar]
  13. Glassman D. M., Coelho A. M., Jr, Carey K. D., Bramblett C. A. Weight growth in savannah baboons: a longitudinal study from birth to adulthood. Growth. 1984 Winter;48(4):425–433. [PubMed] [Google Scholar]
  14. Gurr M. I., Jung R. T., Robinson M. P., James W. P. Adipose tissue cellularity in man: the relationship between fat cell size and number, the mass and distribution of body fat and the history of weight gain and loss. Int J Obes. 1982;6(5):419–436. [PubMed] [Google Scholar]
  15. Hirsch J. Cell number and size as a determinant of subsequent obesity. Curr Concepts Nutr. 1975;3:15–21. [PubMed] [Google Scholar]
  16. Hirsch J., Gallian E. Methods for the determination of adipose cell size in man and animals. J Lipid Res. 1968 Jan;9(1):110–119. [PubMed] [Google Scholar]
  17. Hirsch J., Knittle J. L. Cellularity of obese and nonobese human adipose tissue. Fed Proc. 1970 Jul-Aug;29(4):1516–1521. [PubMed] [Google Scholar]
  18. Häger A., Sjöstrm L., Arvidsson B., Björntorp P., Smith U. Body fat and adipose tissue cellularity in infants: a longitudinal study. Metabolism. 1977 Jun;26(6):607–614. doi: 10.1016/0026-0495(77)90082-8. [DOI] [PubMed] [Google Scholar]
  19. Johnson P. R., Stern J. S., Greenwood M. R., Zucker L. M., Hirsch J. Effect of early nutrition on adipose cellularity and pancreatic insulin release in the Zucker rat. J Nutr. 1973 May;103(5):738–743. doi: 10.1093/jn/103.5.738. [DOI] [PubMed] [Google Scholar]
  20. Jung R. T., Gurr M. I., Robinson M. P., James W. P. Does adipocyte hypercellularity in obesity exist? Br Med J. 1978 Jul 29;2(6133):319–321. doi: 10.1136/bmj.2.6133.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Kissebah A. H., Vydelingum N., Murray R., Evans D. J., Hartz A. J., Kalkhoff R. K., Adams P. W. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab. 1982 Feb;54(2):254–260. doi: 10.1210/jcem-54-2-254. [DOI] [PubMed] [Google Scholar]
  22. Knittle J. L., Hirsch J. Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism. J Clin Invest. 1968 Sep;47(9):2091–2098. doi: 10.1172/JCI105894. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Knittle J. L. Obesity in childhood: a problem in adipose tissue cellular development. J Pediatr. 1972 Dec;81(6):1048–1059. doi: 10.1016/s0022-3476(72)80231-2. [DOI] [PubMed] [Google Scholar]
  24. Krotkiewski M., Björntorp P., Sjöström L., Smith U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest. 1983 Sep;72(3):1150–1162. doi: 10.1172/JCI111040. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Lavau M., Susini C., Knittle J., Blanchet-Hirst S., Greenwood M. R. A reliable photomicrographic method to determining fat cell size and number: application to dietary obesity. Proc Soc Exp Biol Med. 1977 Nov;156(2):251–256. doi: 10.3181/00379727-156-39916. [DOI] [PubMed] [Google Scholar]
  26. Lemonnier D. Effect of age, sex, and sites on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet. J Clin Invest. 1972 Nov;51(11):2907–2915. doi: 10.1172/JCI107115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Lewis D. S., Bertrand H. A., Masoro E. J., McGill H. C., Jr, Carey K. D., McMahan C. A. Preweaning nutrition and fat development in baboons. J Nutr. 1983 Nov;113(11):2253–2259. doi: 10.1093/jn/113.11.2253. [DOI] [PubMed] [Google Scholar]
  28. Masoro E. J. Skeletal muscle lipids. 3. Analysis of the functioning of skeletal muscle lipids during fasting. J Biol Chem. 1967 Mar 25;242(6):1111–1114. [PubMed] [Google Scholar]
  29. McGill H. C., Jr, McMahan C. A., Kruski A. W., Mott G. E. Relationship of lipoprotein cholesterol concentrations to experimental atherosclerosis in baboons. Arteriosclerosis. 1981 Jan-Feb;1(1):3–12. doi: 10.1161/01.atv.1.1.3. [DOI] [PubMed] [Google Scholar]
  30. Miller F. J., Billewicz W. Z., Thomson A. M. Growth from birth to adult life of 442 Newcastle upon Tyne children. Br J Prev Soc Med. 1972 Nov;26(4):224–230. doi: 10.1136/jech.26.4.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Roche A. F. The adipocyte-number hypothesis. Child Dev. 1981 Mar;52(1):31–43. [PubMed] [Google Scholar]
  32. Salans L. B., Cushman S. W., Weismann R. E. Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients. J Clin Invest. 1973 Apr;52(4):929–941. doi: 10.1172/JCI107258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Shapiro L. R., Crawford P. B., Clark M. J., Pearson D. L., Raz J., Huenemann R. L. Obesity prognosis: a longitudinal study of children from the age of 6 months to 9 years. Am J Public Health. 1984 Sep;74(9):968–972. doi: 10.2105/ajph.74.9.968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Sjöström L., Björntorp P. Body composition and adipose cellularity in human obesity. Acta Med Scand. 1974 Mar;195(3):201–211. doi: 10.1111/j.0954-6820.1974.tb08123.x. [DOI] [PubMed] [Google Scholar]
  35. Smith U., Digirolamo M., Blohmé G., Kral J. G., Tisell L. E. Possible systemic metabolic effects of regional adiposity in a patient with Werner's syndrome. Int J Obes. 1980;4(2):153–163. [PubMed] [Google Scholar]
  36. Stiles J. W., Francendese A. A., Masoro E. J. Influence of age on size and number of fat cells in the epididymal depot. Am J Physiol. 1975 Dec;229(6):1561–1568. doi: 10.1152/ajplegacy.1975.229.6.1561. [DOI] [PubMed] [Google Scholar]
  37. Whitelaw A. Infant feeding and subcutaneous fat at birth and at one year. Lancet. 1977 Nov 26;2(8048):1098–1099. doi: 10.1016/s0140-6736(77)90545-1. [DOI] [PubMed] [Google Scholar]

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