Skip to main content
. Author manuscript; available in PMC: 2014 Nov 19.
Published in final edited form as: Nature. 2011 Feb 17;470(7334):338–339. doi: 10.1038/470338a

Figure 1. Possible mechanisms of the anti-diabetic effects of ATM.

Figure 1

In response to metformin, ATM could mediate the phosphorylation (P), and so the activation, of AMPK by phosphorylating LKB1. Alternatively, ATM might activate AMPK independently of LKB1, or reduce blood glucose levels through pathways entirely independent of AMPK.