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. 1986 Nov;78(5):1150–1154. doi: 10.1172/JCI112695

Augmentation of fibroblast proliferation by bleomycin.

P L Moseley, C Hemken, G W Hunninghake
PMCID: PMC423797  PMID: 2429990

Abstract

Bleomycin-induced lung disease is characterized by fibroblast proliferation and pulmonary fibrosis. In these studies, we demonstrate that fibroblasts are relatively resistant to clinically relevant amounts (below 10(-4) U/ml) of bleomycin and that these levels of bleomycin augment fibroblast proliferation in response to various fibroblast growth factors. These observations suggest that one mechanism by which bleomycin causes pulmonary fibrosis is augmentation of fibroblast proliferation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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