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. 2014 Mar 3;20(14):3917–3921. doi: 10.1002/chem.201400407

Table 2.

Optimization studies for the gold-catalyzed cyclization.[a]

graphic file with name chem0020-3917-m2.jpg
Entry Catalyst Additive t [h] Yield [%][b]
1 11/AgNTf2 – 0.5 89
2 12/AgNTf2 – 0.5 89
3 13/AgNTf2 – 0.5 99
4 14 – 0.5 92
5 15/AgNTf2 – 0.5 96
6 16 – 30 76
7 AgNTf2 – >24 –
8 CuI – >24 –
9 Cu(OTf)2 – >24 –
10 PtCl2 – >24 –
11 – 30 mol % TFA >24 –
12 13/AgNTf2 20 mol % 10 >24 –
13 13/AgNTf2 20 mol % 10, 30 mol % TFA 0.5 96

[a] General reaction conditions: 2 (0.3 mmol), AgNTf2 (10 mol %), toluene (1.7 mL), rt. [b] Yield of isolated 17 a.