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. 1986 Dec;78(6):1439–1442. doi: 10.1172/JCI112733

Kappa-chain gene rearrangement in an apparent T-lineage lymphoma.

K Ha-Kawa, J Hara, Y Keiko, A Muraguchi, N Kawamura, S Ishihara, S Doi, H Yabuuchi
PMCID: PMC423886  PMID: 3097073

Abstract

We describe a 10-yr-old boy with T-lineage non-Hodgkin's lymphoma. He had a mediastinal mass, swollen supraclavicular lymph nodes, and pleural effusion. A supraclavicular lymph node biopsy under light microscopy showed a malignant lymphoma of diffuse lymphoblastic type. Most of the cells taken from the malignant pleural effusion expressed T cell-associated antigens such as Leu-1 and OKT 8. To confirm these antigens as T-lineage lymphoma, we examined genomic DNA from malignant cells obtained from the pleural effusion. As was expected, T cell receptor beta-chain gene rearrangements were demonstrated. However, when the immunoglobulin gene organization was analyzed, we detected rearrangements in both the heavy- and kappa-chain genes. To our knowledge, this is the first case in which kappa-chain gene rearrangement was detected in apparent T-lineage cells. These findings provide important information relating to determination of the cellular lineage of lymphoid malignancy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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