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. 1987 Jan;79(1):198–206. doi: 10.1172/JCI112783

Independent effects of aldosterone and potassium on induction of potassium adaptation in rat kidney.

B Stanton, L Pan, H Deetjen, V Guckian, G Giebisch
PMCID: PMC424022  PMID: 3793923

Abstract

We examined the independent effects of a high potassium diet and increased aldosterone levels on the development of renal potassium adaptation. This condition is defined by the increased ability of the kidneys to excrete an acute infusion of potassium. Rats were adrenalectomized (ADX) and received aldosterone at basal levels (0.5 microgram/100 g X d) or at high levels (2.0 micrograms/100 g X d) for 10 d. In each experimental group, animals received either a control diet or a high potassium diet. In ADX animals with basal aldosterone levels, a high potassium intake increased but did not completely restore the ability to excrete potassium and induced proliferation of the basolateral membrane of principal cells in the collecting tubule (i.e., morphologic adaptation). In contrast, increased aldosterone did not induce functional adaptation. Elevated aldosterone and dietary potassium intake were required to produce functional potassium adaptation indistinguishable from that in potassium-loaded, adrenal-intact animals.

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Selected References

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  1. Adam W. R., Goland G. J., Wellard R. M. Renal potassium adaptation in the rat: role of glucocorticoids and aldosterone. Am J Physiol. 1984 Mar;246(3 Pt 2):F300–F308. doi: 10.1152/ajprenal.1984.246.3.F300. [DOI] [PubMed] [Google Scholar]
  2. Alexander E. A., Levinsky N. G. An extrarenal mechanism of potassium adaptation. J Clin Invest. 1968 Apr;47(4):740–748. doi: 10.1172/JCI105769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BERLINER R. W., KENNEDY T. J., Jr, HILTON J. G. Renal mechanisms for excretion of potassium. Am J Physiol. 1950 Aug 1;162(2):348–367. doi: 10.1152/ajplegacy.1950.162.2.348. [DOI] [PubMed] [Google Scholar]
  4. Bia M. J., Tyler K. A., DeFronzo R. A. Regulation of extrarenal potassium homeostasis by adrenal hormones in rats. Am J Physiol. 1982 Jun;242(6):F641–F644. doi: 10.1152/ajprenal.1982.242.6.F641. [DOI] [PubMed] [Google Scholar]
  5. Doucet A., Katz A. I. Renal potassium adaptation: Na-K-ATPase activity along the nephron after chronic potassium loading. Am J Physiol. 1980 May;238(5):F380–F386. doi: 10.1152/ajprenal.1980.238.5.F380. [DOI] [PubMed] [Google Scholar]
  6. Field M. J., Stanton B. A., Giebisch G. H. Differential acute effects of aldosterone, dexamethasone, and hyperkalemia on distal tubular potassium secretion in the rat kidney. J Clin Invest. 1984 Nov;74(5):1792–1802. doi: 10.1172/JCI111598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fine L. G., Yanagawa N., Schultze R. G., Tuck M., Trizna W. Functional profile of the isolated uremic nephron: potassium adaptation in the rabbit cortical collecting tubule. J Clin Invest. 1979 Oct;64(4):1033–1043. doi: 10.1172/JCI109540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Garg L. C., Narang N. Renal adaptation to potassium in the adrenalectomized rabbit. Role of distal tubular sodium-potassium adenosine triphosphatase. J Clin Invest. 1985 Sep;76(3):1065–1070. doi: 10.1172/JCI112059. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hirsch D., Kashgarian M., Boulpaep E. L., Hayslett J. P. Role of aldosterone in the mechanism of potassium adaptation in the initial collecting tubule. Kidney Int. 1984 Dec;26(6):798–807. doi: 10.1038/ki.1984.221. [DOI] [PubMed] [Google Scholar]
  10. Kaissling B., Le Hir M. Distal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake. I. Structural changes. Cell Tissue Res. 1982;224(3):469–492. doi: 10.1007/BF00213746. [DOI] [PubMed] [Google Scholar]
  11. Le Hir M., Kaissling B., Dubach U. C. Distal tubular segments of the rabbit kidney after adaptation to altered Na- and K-intake. II. Changes in Na-K-ATPase activity. Cell Tissue Res. 1982;224(3):493–504. doi: 10.1007/BF00213747. [DOI] [PubMed] [Google Scholar]
  12. Miller P. D., Waterhouse C., Owens R., Cohen E. The effect of potassium loading on sodium excretion and plasma renin activity in Addisonian man. J Clin Invest. 1975 Aug;56(2):346–353. doi: 10.1172/JCI108099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mujais S. K., Chekal M. A., Jones W. J., Hayslett J. P., Katz A. I. Modulation of renal sodium-potassium-adenosine triphosphatase by aldosterone. Effect of high physiologic levels on enzyme activity in isolated rat and rabbit tubules. J Clin Invest. 1985 Jul;76(1):170–176. doi: 10.1172/JCI111942. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mujais S. K., Chekal M. A., Jones W. J., Hayslett J. P., Katz A. I. Regulation of renal Na-K-ATPase in the rat. Role of the natural mineralo- and glucocorticoid hormones. J Clin Invest. 1984 Jan;73(1):13–19. doi: 10.1172/JCI111183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rastegar A., Biemesderfer D., Kashgarian M., Hayslett J. P. Changes in membrane surfaces of collecting duct cells in potassium adaptation. Kidney Int. 1980 Sep;18(3):293–301. doi: 10.1038/ki.1980.139. [DOI] [PubMed] [Google Scholar]
  16. Schon D. A., Backman K. A., Hayslett J. P. Role of the medullary collecting duct in potassium excretion in potassium-adapted animals. Kidney Int. 1981 Nov;20(5):655–662. doi: 10.1038/ki.1981.190. [DOI] [PubMed] [Google Scholar]
  17. Schwartz G. J., Burg M. B. Mineralocorticoid effects on cation transport by cortical collecting tubules in vitro. Am J Physiol. 1978 Dec;235(6):F576–F585. doi: 10.1152/ajprenal.1978.235.6.F576. [DOI] [PubMed] [Google Scholar]
  18. Silva P., Brown R. S., Epstein F. H. Adaptation to potassium. Kidney Int. 1977 Jun;11(6):466–475. doi: 10.1038/ki.1977.64. [DOI] [PubMed] [Google Scholar]
  19. Stanton B. A., Biemesderfer D., Wade J. B., Giebisch G. Structural and functional study of the rat distal nephron: effects of potassium adaptation and depletion. Kidney Int. 1981 Jan;19(1):36–48. doi: 10.1038/ki.1981.5. [DOI] [PubMed] [Google Scholar]
  20. Stanton B. A., Giebisch G. H. Potassium transport by the renal distal tubule: effects of potassium loading. Am J Physiol. 1982 Nov;243(5):F487–F493. doi: 10.1152/ajprenal.1982.243.5.F487. [DOI] [PubMed] [Google Scholar]
  21. Stanton B., Giebisch G., Klein-Robbenhaar G., Wade J., DeFronzo R. A. Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney. J Clin Invest. 1985 Apr;75(4):1317–1326. doi: 10.1172/JCI111832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Stanton B., Janzen A., Klein-Robbenhaar G., DeFronzo R., Giebisch G., Wade J. Ultrastructure of rat initial collecting tubule. Effect of adrenal corticosteroid treatment. J Clin Invest. 1985 Apr;75(4):1327–1334. doi: 10.1172/JCI111833. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tomita K., Pisano J. J., Knepper M. A. Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone. J Clin Invest. 1985 Jul;76(1):132–136. doi: 10.1172/JCI111935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Wade J. B., O'Neil R. G., Pryor J. L., Boulpaep E. L. Modulation of cell membrane area in renal collecting tubules by corticosteroid hormones. J Cell Biol. 1979 May;81(2):439–445. doi: 10.1083/jcb.81.2.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wingo C. S., Seldin D. W., Kokko J. P., Jacobson H. R. Dietary modulation of active potassium secretion in the cortical collecting tubule of adrenalectomized rabbits. J Clin Invest. 1982 Sep;70(3):579–586. doi: 10.1172/JCI110650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Wright F. S. Sites and mechanisms of potassium transport along the renal tubule. Kidney Int. 1977 Jun;11(6):415–432. doi: 10.1038/ki.1977.60. [DOI] [PubMed] [Google Scholar]
  27. Wright F. S., Strieder N., Fowler N. B., Giebisch G. Potassium secretion by distal tubule after potassium adaptation. Am J Physiol. 1971 Aug;221(2):437–448. doi: 10.1152/ajplegacy.1971.221.2.437. [DOI] [PubMed] [Google Scholar]
  28. Young D. B., Jackson T. E. Effects of aldosterone on potassium distribution. Am J Physiol. 1982 Nov;243(5):R526–R530. doi: 10.1152/ajpregu.1982.243.5.R526. [DOI] [PubMed] [Google Scholar]
  29. Young D. B., Paulsen A. W. Interrelated effects of aldosterone and plasma potassium on potassium excretion. Am J Physiol. 1983 Jan;244(1):F28–F34. doi: 10.1152/ajprenal.1983.244.1.F28. [DOI] [PubMed] [Google Scholar]
  30. de Mello-Aires M., Giebisch G., Malnic G. Kinetics of potassium transport across single distal tubules of rat kidney. J Physiol. 1973 Jul;232(1):47–70. doi: 10.1113/jphysiol.1973.sp010256. [DOI] [PMC free article] [PubMed] [Google Scholar]

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